FGFR1 抗体 (N-Term)
Quick Overview for FGFR1 抗体 (N-Term) (ABIN2789361)
抗原
See all FGFR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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序列
- TYFSVNVSDA LPSSEDDDDD DDSSSEEKET DNTKPNRRPV APYWTSPEKM
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预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
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产品特性
- This is a rabbit polyclonal antibody against Fgfr1. It was validated on Western Blot.
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纯化方法
- Affinity Purified
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免疫原
- The immunogen is a synthetic peptide directed towards the N-terminal region of Mouse Fgfr1
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anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 19-48), (N-Term) antibody
FGFR1 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB04521 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 236-362) antibodyFGFR1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (C-Term) antibodyFGFR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 19-48) antibodyFGFR1 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 31-150) antibodyFGFR1 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 5E9 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (pTyr766) antibodyFGFR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (Tyr766) antibodyFGFR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 291-324) antibodyFGFR1 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB50848 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (AA 806-842), (C-Term) antibodyFGFR1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 1440CT772-50-23 unconjugated
anti-Fibroblast Growth Factor Receptor 1 (FGFR1) antibodyFGFR1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 4C3 unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeat freeze-thaw cycles.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
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别名
- Fgfr1
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背景
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Fgfr1 is a Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. It is required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Fgfr1 phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. It promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, Fgfr1 enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation
Alias Symbols: AW208770, Eask, FLG, Fgfr-1, Flt-2, Hspy
Protein Interaction Partner: GZMB, Fgf23, Kl, Frs2,
Protein Size: 822 -
分子量
- 92 kDa
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基因ID
- 14182
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NCBI登录号
- NM_010206, NP_034336
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UniProt
- P16092
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins
抗原
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