-
- 抗原 See all COL4a3 (COL4A3) 抗体
- COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))
-
抗原表位
- N-Term
-
适用
- 人, 小鼠, 豚鼠, 马, 兔
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This COL4a3 antibody is un-conjugated
-
应用范围
- Western Blotting (WB)
- 序列
- GPPGVPGSPG SSRPGLRGAP GWPGLKGSKG ERGRPGKDAM GTPGSPGCAG
- 预测反应
- Guinea Pig: 85%, Horse: 86%, Human: 100%, Mouse: 92%, Rabbit: 85%
- 产品特性
- This is a rabbit polyclonal antibody against COL4A3. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human COL4A3
- Top Product
- Discover our top product COL4A3 Primary Antibody
-
anti-Collagen, Type IV, alpha 3 (COL4A3) (AA 1428-1670) antibody
COL4A3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type IV, alpha 3 (COL4A3) (AA 1571-1670) antibodyCOL4A3 适用: 小鼠, 大鼠 ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type IV, alpha 3 (COL4A3) (AA 375-424) antibodyCOL4A3 适用: 人, 小鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type IV, alpha 3 (COL4A3) (AA 793-842) antibodyCOL4A3 适用: 人, 猴, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type IV, alpha 3 (COL4A3) (C-Term) antibodyCOL4A3 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type IV, alpha 3 (COL4A3) (AA 801-850) antibodyCOL4A3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type IV, alpha 3 (COL4A3) (Cleaved-Leu1425) antibodyCOL4A3 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type IV, alpha 3 (COL4A3) (Cleaved-Pro1426) antibodyCOL4A3 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type IV, alpha 3 (COL4A3) (AA 1427-1668) antibodyCOL4A3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Collagen, Type IV, alpha 3 (COL4A3) (AA 141-173) antibodyCOL4A3 适用: 人 WB 宿主: 兔 Polyclonal RB54513 unconjugated
-
- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
-
Antigen size: 1637 AA
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
-
- 抗原
- COL4a3 (COL4A3) (Collagen, Type IV, alpha 3 (COL4A3))
- 别名
- COL4A3 (COL4A3 产品)
- 别名
- zTumstatin antibody, [a]3(IV) antibody, alpha3(IV) antibody, collagen type IV alpha 3 chain antibody, collagen, type IV, alpha 3 antibody, COL4A3 antibody, col4a3 antibody, Col4a3 antibody
- 背景
-
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. There are multiple alternate transcripts that appear to be unique to this human alpha 3 gene and alternate splicing is restricted to the six exons that encode this C-terminal domain. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Some exons of this gene are interspersed with exons of an uncharacterized gene which is on the opposite strand.
Alias Symbols: -
Protein Interaction Partner: VHL, UBC, SERPINE2, OSM, MFAP2, FBLN2, FN1, DCN, CD93, MMP9, APP, SAA1, MATN2, TGFBI, CAMK2B, USH2A, ANTXR2, COL4A3BP, HABP2,
Protein Size: 1637 - 分子量
- 156 kDa
- 基因ID
- 1285
- NCBI登录号
- NM_031362, NP_112730
- UniProt
- E7ENN2
- 途径
- Sensory Perception of Sound, Positive Regulation of Endopeptidase Activity
-
You are here:
