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FAS 抗体 (N-Term)

Name: FAS 抗体 (N-Term)
SKU: ABIN2787943
Availability: OutOfStock

FAS 适用: 人, Pig, 山羊 WB 宿主: 兔 Polyclonal unconjugated

WB Suggested Anti-FAS Antibody Titration: 0. (FAS 抗体 (N-Term))

2 images

产品编号 ABIN2787943

发货至: 中国

Datasheet as PDF

抗原 See all FAS 抗体

FAS (TNF Receptor Superfamily, Member 6 (FAS))
抗原表位
25

16

16

8

7

6

5

5

4

4

4

4

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
209

67

62

19

5

4

2

2

1
人, Pig, 山羊
宿主
157

86

4

2

1

1

1

1
兔
Compatible Secondaries
克隆类型
155

96

1
多克隆
标记
119

27

25

12

10

7

4

4

3

3

3

3

3

3

3

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1
This FAS antibody is un-conjugated
应用范围
162

115

72

64

35

34

30

26

26

20

18

9

8

6

5

4

4

2

2

2

2

1

1
Western Blotting (WB)

序列

GLHHDGQFCH KPCPPGERKA RDCTVNGDEP DCVPCQEGKE YTDKAHFSSK

预测反应

Goat: 100%, Human: 100%, Pig: 93%

产品特性

This is a rabbit polyclonal antibody against FAS. It was validated on Western Blot.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human FAS

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FAS 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

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FAS 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

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FAS 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 5B4 unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 1-335) antibody
FAS 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1B6 unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 20-119) antibody
FAS 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2G3 unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 335 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

FAS (TNF Receptor Superfamily, Member 6 (FAS))

别名

FAS (FAS 产品)

别名

ALPS1A antibody, APO-1 antibody, APT1 antibody, CD95 antibody, FAS1 antibody, FASTM antibody, TNFRSF6 antibody, AI196731 antibody, APO1 antibody, TNFR6 antibody, Tnfrsf6 antibody, lpr antibody, Fas cell surface death receptor antibody, Fas (TNF receptor superfamily member 6) antibody, FAS antibody, Fas antibody, fas antibody

背景

FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
Alias Symbols: ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Protein Interaction Partner: FADD, CAV1, FAS, APOA5, TMX1, UBQLN1, MBD4, TP63, TCAP, BAG6, UBC, HNRNPC, GADD45A, CCND3, ATP6V0B, SQSTM1, Ube2i, PRAM1, RARA, PML, DAXX, FASLG, TRADD, MAP3K5, BMX, Traf1, FAF1, FAF2, TRAF3, KRIT1, TNF, BRE, LRIF1, FEM1B, FBF1, FAIM2, CASP8AP2, C14orf1,
Protein Size: 335

分子量

36 kDa

基因ID

355

NCBI登录号

NM_000043, NP_000034

UniProt

P25445

途径

p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity