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FAS 抗体 (N-Term)

Name: FAS 抗体 (N-Term)
SKU: ABIN3044338
Availability: OutOfStock

This 兔多克隆 antibody specifically detects FAS in WB 和 IHC. It exhibits reactivity toward 大鼠和小鼠. It has been mentioned in 19+ publications

Western blot analysis of FAS expression in rat liver extract ( Lane 1), rat spleen extract ( Lane 2), rat brain extract ( Lane 3) and rat cardiac muscle extract ( Lane 4). (FAS 抗体 (N-Term))

Western blot analysis of FAS expression in mouse liver extract ( Lane 1), mouse spleen extract ( Lane 2), mouse brain extract ( Lane 3) mouse kidney extract ( Lane 4), mouse thymus extract ( Lane 5), mouse lung extract ( Lane 6), HEPA1-6 whole cell lysates ( Lane 7) and NIH3T3 whole cell lysates ( Lane 8). (FAS 抗体 (N-Term))

Anti-CD95 antibody, Western blotting Lane 1: Recombinant Mouse FAS Protein 10ng Lane 2: Recombinant Mouse FAS Protein 5ng Lane 3: Recombinant Mouse FAS Protein 2. (FAS 抗体 (N-Term))

Anti-CD95 antibody, IHC(P) IHC(P): Rat Spleen Tissue Lysate (FAS 抗体 (N-Term))

IHC

4 images

(19 references)

产品编号 ABIN3044338

发货至: 中国

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Quick Overview for FAS 抗体 (N-Term) (ABIN3044338)

抗原

See all FAS 抗体

FAS (TNF Receptor Superfamily, Member 6 (FAS))

适用

大鼠, 小鼠

宿主

兔

克隆类型

多克隆

标记

This FAS antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product FAS Primary Antibody

抗原表位
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N-Term

原理

Anti-Fas Antibody

序列

YTDRKHYSDK CRRCAFCDEG HGL

特异性

No cross reactivity with other proteins.

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Fas Antibody. Tested in IHC, WB applications. This antibody reacts with Mouse, Rat.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of rat Fas.

亚型

IgG
anti-TNF Receptor Superfamily, Member 6 (FAS) antibody
FAS 适用: 人 WB, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 4F8H6 unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 150-250) antibody
FAS 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) antibody
FAS 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 26-96) antibody
FAS 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal FAS-3112 unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 22-169) antibody
FAS 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 22-172) antibody
FAS 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 21-170) antibody
FAS 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 20-119) antibody
FAS 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 5B4 unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 20-119) antibody
FAS 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 2G3 unconjugated

anti-TNF Receptor Superfamily, Member 6 (FAS) (AA 1-335) antibody
FAS 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1B6 unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Mouse, Rat , -Western blot, 0.1-0.5 μg/mL, Mouse, Rat

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and IHC(F).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
Yeung, Wang, Yao, Liang, Tenny Chung, Chuai, Lee, Yang: "BRE modulates granulosa cell death to affect ovarian follicle development and atresia in the mouse." in: Cell death & disease, Vol. 8, Issue 3, pp. e2697, (2017) (PubMed).

Gao, Liu, Huang, Zhang, Mei, Wang, Gong, Zhao, Xie, Ma, Qian: "HSP70 inhibits stress-induced cardiomyocyte apoptosis by competitively binding to FAF1." in: Cell stress & chaperones, Vol. 20, Issue 4, pp. 653-61, (2016) (PubMed).

Liu, Xu, Zhao, Xia, Song, Gu, Liu, Bian, Yuan, Liu: "Osteoprotegerin Induces Apoptosis of Osteoclasts and Osteoclast Precursor Cells via the Fas/Fas Ligand Pathway." in: PLoS ONE, Vol. 10, Issue 11, pp. e0142519, (2016) (PubMed).

Li, Xu, Jiang, Zhao, Ge, Zheng: "Significance of Fas and FasL protein expression in cardiac carcinoma and local lymph node tissues." in: International journal of clinical and experimental pathology, Vol. 8, Issue 9, pp. 11915-20, (2016) (PubMed).

Li, Wu, Sun, Zhao, Liu, Zhang: "Croton Tiglium Extract Induces Apoptosis via Bax/Bcl-2 Pathways in Human Lung Cancer A549 Cells" in: Asian Pacific journal of cancer prevention : APJCP, Vol. 17, Issue 11, pp. 4893-4898, (2016) (PubMed).

Qin, Ma, Yang, Hu, Zhou, Fu, Tian, Liu, Xu, Shen: "A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes." in: Natural products and bioprospecting, Vol. 5, Issue 3, pp. 159-66, (2015) (PubMed).

Kan, Zhou, Jin, Yang: "Effects of PDTC on NF-?B expression and apoptosis in rats with severe acute pancreatitis-associated lung injury." in: International journal of clinical and experimental medicine, Vol. 8, Issue 3, pp. 3258-70, (2015) (PubMed).

Liu, Su, Zhang, Zhang, Wang, Qian: "Rhodiola rosea suppresses thymus T-lymphocyte apoptosis by downregulating tumor necrosis factor-?-induced protein 8-like-2 in septic rats." in: International journal of molecular medicine, Vol. 36, Issue 2, pp. 386-98, (2015) (PubMed).

Jiang, Li, Zhou, Wang, Zhang, Wang: "Colistin-induced apoptosis in PC12 cells: involvement of the mitochondrial apoptotic and death receptor pathways." in: International journal of molecular medicine, Vol. 33, Issue 5, pp. 1298-304, (2014) (PubMed).

Wu, Hu, Liu, Cao, Xu, Li, Li: "Nature and mechanisms of hepatocyte apoptosis induced by D-galactosamine/lipopolysaccharide challenge in mice." in: International journal of molecular medicine, Vol. 33, Issue 6, pp. 1498-506, (2014) (PubMed).

Weng, Xie, Yi, Huang, Luo, Du, Chen, Liu, Chen, Chen: "Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritis." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 22, Issue 8, pp. 1197-205, (2014) (PubMed).

Liu, Shan, Dong, Liu, Ma, Liu: "Combined early fluid resuscitation and hydrogen inhalation attenuates lung and intestine injury." in: World journal of gastroenterology, Vol. 19, Issue 4, pp. 492-502, (2013) (PubMed).

Li, Xu, Chu, Gao, Wang, Nie, Yang, Lv: "Molecular mechanism of inhibitory effects of CD59 gene on atherosclerosis in ApoE (-/-) mice." in: Immunology letters, Vol. 156, Issue 1-2, pp. 68-81, (2013) (PubMed).

Ma, Zhang, Zhang, Yang, Meng, Zhang, Zhou: "The effect of esculentoside A on lupus nephritis-prone BXSB mice." in: Archives of medical science : AMS, Vol. 9, Issue 2, pp. 354-60, (2013) (PubMed).

Liu, Liu, Li, Wang, Zhao: "Hydrogen sulfide donor regulates alveolar epithelial cell apoptosis in rats with acute lung injury." in: Chinese medical journal, Vol. 126, Issue 3, pp. 494-9, (2013) (PubMed).

Li, Xia, Wang, Li, Xue, Wu, Ye: "Relationship between aberrant methylation of FAS promoter and biological behavior of bladder urothelial carcinoma." in: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, Vol. 31, Issue 6, pp. 794-8, (2011) (PubMed).

Li, Peng, Li, Liu, Liang, Zhang: "Clinical significance of Fas and FasL protein expression in gastric carcinoma and local lymph node tissues." in: World journal of gastroenterology, Vol. 16, Issue 10, pp. 1274-8, (2010) (PubMed).

Li, Chu, Gao, Li: "Apoptotic mechanism of MCF-7 breast cells in vivo and in vitro induced by photodynamic therapy with C-phycocyanin." in: Acta biochimica et biophysica Sinica, Vol. 42, Issue 1, pp. 80-9, (2009) (PubMed).

Liu, Zhang, Zhang, Zhu, Tian: "Construction and identification of Fas-targeting siRNA-expressing plasmid." in: Journal of Zhejiang University. Science. B, Vol. 6, Issue 7, pp. 673-7, (2005) (PubMed).
抗原

FAS (TNF Receptor Superfamily, Member 6 (FAS))

别名

FAS

背景

Background: FAS (also known as surface antigen APO1 or CD95) is a member of the tumour-necrosis receptor factor family of death receptors, can induce apoptosis or, conversely, can deliver growth stimulatory signals. It acts as an inducer of both neurite growth in vitro and accelerated recovery after nerve injury in vivo. Fas antigen is expressed and functional on papillary thyroid cancer cells and this may have potential therapeutic significance. The FAS antigen shows structural homology with a number of cell surface receptors, including tumor necrosis factor (TNF) receptors and the low-affinity nerve growth factor receptor (NGFR) and is mapped to 10q24.1. And the FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signalling pathway has been shown to participate in immune escape and tumorigenesis.
Gene Full Name: Fas cell surface death receptor
Sequence Similarities: Contains 1 death domain.

分子量

12 kDa

基因ID

246097

UniProt

Q63199

途径

p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity