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- 抗原 See all SAV1 抗体
- SAV1 (Salvador Homolog 1 (SAV1))
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠, 犬, 马, Pig, 兔, Cow
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SAV1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- PCAPSVPRYD QPPPITYQPQ QTERNQSLLV PANPYHTAEI PDWLQVYARA
- 预测反应
- Cow: 93%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against Sav1. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Sav1
- Top Product
- Discover our top product SAV1 Primary Antibody
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anti-Salvador Homolog 1 (SAV1) (AA 300-383) antibody
SAV1 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 3B2 unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 1-210) antibodySAV1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 1-210) antibodySAV1 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) antibodySAV1 适用: 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) antibodySAV1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 1-383) antibodySAV1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 300-383) antibodySAV1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) antibodySAV1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 1-383) antibodySAV1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Salvador Homolog 1 (SAV1) (AA 65-92) antibodySAV1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 386 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- SAV1 (Salvador Homolog 1 (SAV1))
- 别名
- Sav1 (SAV1 产品)
- 别名
- SAV antibody, WW45 antibody, WWP4 antibody, 1700040G09Rik antibody, Salv antibody, Sav antibody, Wwp3 antibody, Wwp4 antibody, salvador family WW domain containing protein 1 antibody, salvador family WW domain containing 1 antibody, SAV1 antibody, Sav1 antibody
- 背景
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Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.
Alias Symbols: 1700040G09Rik, Sav, WW45, Wwp3, Wwp4
Protein Size: 386 - 分子量
- 42 kDa
- 基因ID
- 64010
- NCBI登录号
- NM_022028, NP_071311
- UniProt
- Q8VEB2
- 途径
- Stem Cell Maintenance
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