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SAV1 抗体

(Salvador Homolog 1 (SAV1))
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012].
SAV1 抗体  (AA 300-383) SAV1 抗体  (AA 300-383) SAV1 抗体 (AA 300-383) (ABIN566210)

SAV1 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 3B2 unconjugated

SAV1 抗体  (AA 1-210) SAV1 抗体  (AA 1-210) SAV1 抗体 (AA 1-210) (ABIN7166095)

SAV1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

SAV1 抗体  (AA 1-210) SAV1 抗体  (AA 1-210) SAV1 抗体 (AA 1-210) (ABIN7166096)

SAV1 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

SAV1 抗体 by Grade

Find SAV1 抗体 with a specific Grade. The Grade listed below are among those available. Click on a link to go to the corresponding products.

SAV1 抗体 by 适用

Find SAV1 抗体 for a variety of species such as anti-Human SAV1, anti-Mouse SAV1, anti-Rat SAV1. The species listed below are among those available. Click on a link to go to the corresponding products.

SAV1 抗体 by 应用范围

Find SAV1 抗体 validated for a specific application such as WB, ELISA, IHC, IF. Some of the available applications are listed below. Click on a link to go to the corresponding products.

SAV1 抗体 by 抗体来源

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SAV1 抗体 by 抗原表位

Find SAV1 抗体 with a specific epitope. The epitopes listed below are among those available. Click on a link to go to the corresponding products.

SAV1 抗体 by 克隆形成能力

Find available monoclonal or polyclonal SAV1 抗体. Click on a link to go to the corresponding products.

SAV1 抗体 by 克隆

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SAV1 抗体 by 标记

Find SAV1 抗体 with a specific conjugate such as APC, Biotin, FITC. The conjugates listed below are among those available. Click on a link to go to the corresponding products.

Popular SAV1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF, IP
Validations
  • (6)
  • (6)
Cat. No. ABIN566210
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (5)
Cat. No. ABIN7166095
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF, IP
Validations
  • (5)
Cat. No. ABIN7166096
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse, Rat
Application IHC, IF
Validations
  • (2)
Cat. No. ABIN7075505
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7247840
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (2)
Cat. No. ABIN528430
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN566209
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN528429
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB
Validations
  • (1)
Cat. No. ABIN7264996
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IHC (p)
Validations
  • (1)
Cat. No. ABIN1932759
Quantity 200 μL
Datasheet Datasheet
Reactivity Bat, Dog, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application WB, IHC, IHC (p)
Validations
  • (1)
Cat. No. ABIN6754965
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC
Validations
Cat. No. ABIN6989879
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
Cat. No. ABIN263166
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
Cat. No. ABIN2580122
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
Cat. No. ABIN2580121
Quantity 200 μL
Datasheet Datasheet

Latest Publications for our SAV1 抗体

Leach, Heallen, Zhang, Rahmani, Morikawa, Hill, Segura, Willerson, Martin: "Hippo pathway deficiency reverses systolic heart failure after infarction." in: Nature, Vol. 550, Issue 7675, pp. 260-264, (2018) (PubMed).

Kai, Tsukamoto, Hijiya, Tokunaga, Nakada, Uchida, Daa, Iha, Takahashi, Nomura, Sato, Mimata, Ikawa, Seto, Matsuura, Moriyama: "Kidney-specific knockout of Sav1 in the mouse promotes hyperproliferation of renal tubular epithelium through suppression of the Hippo pathway." in: The Journal of pathology, Vol. 239, Issue 1, pp. 97-108, (2016) (PubMed).

Schütte, Bisht, Heukamp, Kebschull, Florin, Haarmann, Hoffmann, Bendas, Buettner, Brossart, Feldmann: "Hippo signaling mediates proliferation, invasiveness, and metastatic potential of clear cell renal cell carcinoma." in: Translational oncology, Vol. 7, Issue 2, pp. 309-21, (2014) (PubMed).

Park, Kim, Won, Jeon, Oh, Lee, Kim, Lee: "Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPAR?." in: PLoS ONE, Vol. 7, Issue 1, pp. e30983, (2012) (PubMed).

Li, Luo, Li, Wang, Xiao, Tao, Gong, Hu: "Screening of binding proteins that interact with human Salvador 1 in a human fetal liver cDNA library by the yeast two-hybrid system." in: Molecular biology reports, Vol. 39, Issue 8, pp. 8225-30, (2012) (PubMed).

Murakami, Mizuno, Taniguchi, Fujii, Ishiguro, Fukui, Akatsuka, Horio, Hida, Kondo, Toyokuni, Osada, Sekido: "LATS2 is a tumor suppressor gene of malignant mesothelioma." in: Cancer research, Vol. 71, Issue 3, pp. 873-83, (2011) (PubMed).

Mardin, Lange, Baxter, Hardy, Scholz, Fry, Schiebel: "Components of the Hippo pathway cooperate with Nek2 kinase to regulate centrosome disjunction." in: Nature cell biology, Vol. 12, Issue 12, pp. 1166-76, (2010) (PubMed).

Yoo, Soung, Lee, Park, Kim, Nam, Han, Kim, Lee, Lee: "Mutational analysis of salvador gene in human carcinomas." in: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Vol. 111, Issue 6, pp. 595-8, (2003) (PubMed).

Aliases for SAV1 抗体

salvador family WW domain containing protein 1 (SAV1) 抗体
salvador family WW domain containing 1 (Sav1) 抗体
salvador family WW domain containing protein 1 (Sav1) 抗体
1700040G09Rik 抗体
Salv 抗体
SAV 抗体
Sav 抗体
WW45 抗体
Wwp3 抗体
WWP4 抗体
Wwp4 抗体
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