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Presenilin 2 抗体 (N-Term)

Name: Presenilin 2 抗体 (N-Term)
SKU: ABIN2781802
Availability: OutOfStock

This anti-Presenilin 2 antibody is a 兔多克隆 antibody detecting Presenilin 2 in WB 和 IHC. Suitable for 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔和斑马鱼.

WB Suggested Anti-PSEN2 Antibody Titration: 0. (Presenilin 2 抗体 (N-Term))

WB Suggested Anti-PSEN2 Antibody Positive Control: Lane 1: 80ug rat brain extract Lane 2: 80ug mouse brain extract Primary Antibody Dilution : 1:500 Secondary Antibody : IRDye 800 CW goat anti-rabbit from Li-COR Bioscience Secondry Antibody Dilution : 1:20,000 Submitted by: Dr. (Presenilin 2 抗体 (N-Term))

PSEN2 antibody - N-terminal region Formalin Fixed Paraffin Embedded Tissue: Human Pineal Tissue Observed Staining: Cytoplasm in Human Pineal Tissue Primary Antibody Concentration: 1:100 Other Working Concentrations: 1/600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0. (Presenilin 2 抗体 (N-Term))

IHC

IHC

4 images

产品编号 ABIN2781802

发货至: 中国

Quick Overview for Presenilin 2 抗体 (N-Term) (ABIN2781802)

抗原

See all Presenilin 2 (PSEN2) 抗体

Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

适用

人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼

宿主

兔

克隆类型

多克隆

标记

This Presenilin 2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product PSEN2 Primary Antibody

抗原表位
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N-Term

序列

VVVATIKSVR FYTEKNGQLI YTPFTEDTPS VGQRLLNSVL NTLIMISVIV

预测反应

Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 85%

产品特性

This is a rabbit polyclonal antibody against PSEN2. It was validated on Western Blot and immunohistochemistry.

纯化方法

Affinity Purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human PSEN2
anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (N-Term) antibody
PSEN2 适用: 人, 大鼠, 小鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 39-51), (N-Term) antibody
PSEN2 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 33-48), (Intracellular) antibody
PSEN2 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 319-334) antibody
PSEN2 适用: 人, 大鼠 WB, IHC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 101-150) antibody
PSEN2 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马, 兔, 猴, Bat, Hamster, Pig, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) antibody
PSEN2 适用: 人, 大鼠, 小鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 32-65), (N-Term) antibody
PSEN2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB30801 unconjugated

anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 7-77) antibody
PSEN2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 32-65) antibody
PSEN2 适用: 人 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

anti-Presenilin 2 (Alzheimer Disease 4) (PSEN2) (AA 51-150) antibody
PSEN2 适用: 人, 大鼠, 小鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilutions should be determined experimentally by the investigator.

说明

Antigen size: 448 AA

限制

仅限研究用
状态

Liquid

浓度

Lot specific

缓冲液

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freeze-thaw cycles.

储存条件

-20 °C

储存方法

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
抗原

Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

别名

PSEN2

背景

Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes.Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1, PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Two alternative transcripts of PSEN2 have been identified.
Alias Symbols: AD3L, AD4, PS2, STM2, CMD1V
Protein Interaction Partner: UBC, TRAF6, PSENEN, APH1A, NCSTN, PSEN2, PSEN1, APH1B, SPC24, RNF32, EVI5L, CEP55, FBXL12, EXOC6, ECSIT, PDCD4, IFIT5, EID1, MAST1, ECD, MGEA5, LIPF, RHEB, NOS3, IFIT3, DNAJB1, HPS1, GCDH, ELAVL1, DYNC1H1, CHKA, APP, ACTG1, AAMP, UBQLN1, KCNIP4, DOCK3, ME
Protein Size: 448

分子量

49 kDa

基因ID

5664

NCBI登录号

NM_000447, NP_000438

UniProt

P49810

途径

Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway