JARID2 抗体 (Middle Region)
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- 抗原 See all JARID2 抗体
- JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
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抗原表位
- Middle Region
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适用
- 人, 大鼠, 小鼠, 兔, 豚鼠, 犬
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This JARID2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- NASSSCQSTP RKGKTHKHVH NGHVFNGSSR SAREKEPAHK HRSKEATPGK
- 预测反应
- Dog: 79%, Guinea Pig: 79%, Human: 79%, Mouse: 100%, Rabbit: 79%, Rat: 79%
- 产品特性
- This is a rabbit polyclonal antibody against Jarid2. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the middle region of mouse Jarid2
- Top Product
- Discover our top product JARID2 Primary Antibody
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anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 1097-1246) antibody
JARID2 适用: 人 WB, ELISA, ICC, IHC, FACS 宿主: 小鼠 Monoclonal 7H1B3 unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 1-159) antibodyJARID2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 1130-1229) antibodyJARID2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 1-100) antibodyJARID2 适用: 人, 小鼠 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) antibodyJARID2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 301-400) antibodyJARID2 适用: 人, 大鼠 WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 1107-1141), (C-Term) antibodyJARID2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB52505 unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 435-468) antibodyJARID2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB52498 unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 201-250) antibodyJARID2 适用: 人, 小鼠, 兔, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Jumonji, AT Rich Interactive Domain 2 (JARID2) (AA 215-264) antibodyJARID2 适用: 人, 小鼠, 豚鼠, Cow, Pig, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 1234 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))
- 别名
- Jarid2 (JARID2 产品)
- 别名
- JMJ antibody, Jmj antibody, jumonji antibody, JARID2 antibody, jarid2 antibody, jmj antibody, si:dkey-211c3.1 antibody, Jumonji antibody, jarid2-a antibody, jarid2-b antibody, jarid2.S antibody, jarid2b antibody, jumonji and AT-rich interaction domain containing 2 antibody, jumonji, AT rich interactive domain 2 antibody, jumonji, AT rich interactive domain 2a antibody, jumonji, AT rich interactive domain 2b antibody, jumonji and AT-rich interaction domain containing 2 L homeolog antibody, JARID2 antibody, Jarid2 antibody, jarid2a antibody, jarid2 antibody, jarid2b antibody, jarid2.L antibody
- 背景
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Jarid2 is a regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis.Jarid2 acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes.Jarid2 binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells.Jarid2 does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases.Jarid2 also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5.Jarid2 participates in the negative regulation of cell proliferation signaling.
Alias Symbols: AI317256, AU045941, C79929, C79931, Jmj, jumonji
Protein Interaction Partner: Rb1, Suz12, Ewsr1, Ell, Eed, Aebp2, Morc3, Setx, Stk38l, Thrap3, Ice1, Stk38, Bclaf1, Trim35, Rbbp4, Mtf2, Ezh2, Ezh1,
Protein Size: 1234 - 分子量
- 137 kDa
- 基因ID
- 16468
- NCBI登录号
- NM_021878, NP_068678
- UniProt
- Q62315
- 途径
- Chromatin Binding
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