KAT2B 抗体 (N-Term)
Quick Overview for KAT2B 抗体 (N-Term) (ABIN2779660)
抗原
See all KAT2B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - N-Term
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序列
 - LFKLLRKSIL QRGKPVVEGS LEKKPPFEKP SIEQGVNNFV QYKFSHLPAK
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预测反应
 - Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 90%
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产品特性
 - This is a rabbit polyclonal antibody against PCAF. It was validated on Western Blot using a cell lysate as a positive control.
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纯化方法
 - Protein A purified
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免疫原
 - The immunogen is a synthetic peptide directed towards the N terminal region of human PCAF
 
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应用备注
 - Optimal working dilutions should be determined experimentally by the investigator.
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说明
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Antigen size: 832 AA
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - Lot specific
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缓冲液
 - Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
 - Sodium azide
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注意事项
 - This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
 - Avoid repeated freeze-thaw cycles.
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储存条件
 - -20 °C
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储存方法
 - For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
 
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- KAT2B (K(lysine) Acetyltransferase 2B (KAT2B))
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别名
 - PCAF
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背景
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                        CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. PCAF associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.
Alias Symbols: P, CAF, PCAF, P/CAF
Protein Interaction Partner: MDM2, HNRNPD, ACLY, KLF2, E2F1, VHL, IRF1, TAL1, TAF12, TAF10, TAF9, TADA2A, RB1, HIST1H1B, TAF5L, TAF6L, TADA3, SUPT3H, TWIST1, PDK1, AKT1, UBC, SIAH2, UBE2D3, UBE2D1, TP73, TP53, SRC, PGR, YEATS2, MBIP, WDR5, PTEN, DR1, HIF1A, HIST2H3C, CHEK2, HIST1H4A,
Protein Size: 832 - 
                                            
分子量
 - 93 kDa
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基因ID
 - 8850
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NCBI登录号
 - NM_003884, NP_003875
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UniProt
 - Q92831
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途径
 - p53 Pathway, Regulation of Carbohydrate Metabolic Process
 
抗原
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