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- 抗原 See all Band 3/AE1 (SLC4A1) 抗体
- Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))
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抗原表位
- N-Term
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适用
- 人, 兔, 马
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Band 3/AE1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- PSQPLLPQHS SLETQLFCEQ GDGGTEGHSP SGILEKIPPD SEATLVLVGR
- 预测反应
- Horse: 85%, Human: 100%, Rabbit: 85%
- 产品特性
- This is a rabbit polyclonal antibody against SLC4A1. It was validated on Western Blot using a cell lysate as a positive control.
- 纯化方法
- Affinity Purified
- 免疫原
- The immunogen is a synthetic peptide directed towards the N terminal region of human SLC4A1
- Top Product
- Discover our top product SLC4A1 Primary Antibody
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anti-Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) (AA 35-290) antibody
SLC4A1 适用: 人 ELISA, WB, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) (AA 1-353) antibodySLC4A1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) (AA 28-365) antibodySLC4A1 适用: 人, 大鼠, 小鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) (AA 261-360) antibodySLC4A1 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 2D5 unconjugated
anti-Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) (AA 1-911) antibodySLC4A1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) (AA 184-233) antibodySLC4A1 适用: 人, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) antibodySLC4A1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) (AA 148-298) antibodySLC4A1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) antibodySLC4A1 适用: 人 ELISA, WB, IF, Coat 宿主: 小鼠 Monoclonal Q1-156 unconjugated
anti-Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1) (Internal Region) antibodySLC4A1 适用: 人, 小鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 911 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- Band 3/AE1 (SLC4A1) (Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))
- 别名
- SLC4A1 (SLC4A1 产品)
- 别名
- AE1 antibody, BND3 antibody, CD233 antibody, DI antibody, EMPB3 antibody, EPB3 antibody, FR antibody, RTA1A antibody, SW antibody, WD antibody, WD1 antibody, WR antibody, Ae1 antibody, Empb3 antibody, l11Jus51 antibody, ae1 antibody, band3 antibody, MGC152771 antibody, zgc:111889 antibody, zgc:152771 antibody, si:dz180g5.1 antibody, LOC100136769 antibody, slc4a1 antibody, wd1 antibody, bnd3 antibody, epb3 antibody, cd233 antibody, empb3 antibody, rta1a antibody, MGC80391 antibody, SLC4A1 antibody, BB3 antibody, EAT antibody, solute carrier family 4 member 1 (Diego blood group) antibody, solute carrier family 4 (anion exchanger), member 1 antibody, solute carrier family 4 (anion exchanger), member 1a (Diego blood group) antibody, Band 3 antibody, erythrocyte membrane protein band 4.1 like 3 antibody, solute carrier family 4 member 1 (Diego blood group) L homeolog antibody, solute carrier family 4 member 1 antibody, SLC4A1 antibody, Slc4a1 antibody, slc4a1a antibody, LOC100136769 antibody, EPB41L3 antibody, slc4a1.L antibody, slc4a1 antibody
- 背景
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The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40 kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis.
Alias Symbols: DI, FR, SW, WD, WR, AE1, CHC, SAO, WD1, BND3, EPB3, SPH4, CD233, EMPB3, RTA1A
Protein Interaction Partner: UBC, PIN1, HECW2, CBX8, CBX5, MDC1, TRPM8, TXLNG, SBDS, TTC4, SUMO2, Mad2l2,
Protein Size: 911 - 分子量
- 102 kDa
- 基因ID
- 6521
- NCBI登录号
- NM_000342, NP_000333
- UniProt
- P02730
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