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Band 3/AE1 产品

(Solute Carrier Family 4, Anion Exchanger, Member 1 (erythrocyte Membrane Protein Band 3, Diego Blood Group) (SLC4A1))

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The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008].

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Featured Band 3/AE1 Categories

Band 3/AE1 抗体

High quality antibodies with extensive validation data.

Band 3/AE1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Band 3/AE1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, WB, IHC (p), ICC, IHC (fro)
Validations
  • (8)
Cat. No. ABIN7441895
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (4)
Cat. No. ABIN7270459
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC (p), IHC (fro)
Validations
  • (5)
Cat. No. ABIN3043930
Quantity 100 μg
Datasheet Datasheet

Recommended Band 3/AE1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125166
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1320468
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3132501
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our Band 3/AE1 Products

Govekar, Kawle, Thomas, Advani, Pv, Zingde: "Eryptotic phenotype in chronic myeloid leukemia: contribution of neutrophilic cathepsin g." in: Anemia, Vol. 2012, pp. 659303, (2012) (PubMed).

Synonyms and alternative names related to Band 3/AE1

solute carrier family 4 member 1 (Diego blood group) (SLC4A1), solute carrier family 4 (anion exchanger), member 1 (Slc4a1), solute carrier family 4 (anion exchanger), member 1a (Diego blood group) (slc4a1a), Band 3 (LOC100136769), erythrocyte membrane protein band 4.1 like 3 (EPB41L3), solute carrier family 4 member 1 (Diego blood group) L homeolog (slc4a1.L), solute carrier family 4 member 1 (SLC4A1), solute carrier family 4 member 1 (Diego blood group) (slc4a1), solute carrier family 4 member 1 (Slc4a1), AE1, Ae1, ae1, band3, BB3, BND3, bnd3, CD233, cd233, DI, EAT, EMPB3, Empb3, empb3, EPB3, epb3, FR, l11Jus51, LOC100136769, MGC80391, MGC152771, RTA1A, rta1a, si:dz180g5.1, slc4a1, SLC4A1, SW, WD, WD1, wd1, WR, zgc:111889, zgc:152771

Protein level used designations for Band 3/AE1

  • Diego blood group
  • Froese blood group
  • Swann blood group
  • Waldner blood group
  • Wright blood group
  • anion exchange protein 1
  • anion exchanger 1
  • anion exchanger-1
  • band 3 anion transport protein
  • erythrocyte membrane protein band 3
  • erythroid anion exchange protein
  • solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)
  • solute carrier family 4, anion exchanger, number 1
  • AE 1
  • MEB3
  • solute carrier family 4 member 1
  • solute carrier family 4, anion exchanger, member 1
  • ret
  • retsina
  • AE1/band 3
  • erythroid anion exchanger 1
  • Band 3
  • band 4.1-like protein 3-like
  • solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3)
  • band 3 anion transport protein-like
  • erythroid-specific band 3 protein
  • erythrocyte anion transport protein
  • Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3)
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