RFWD2 抗体 (Middle Region)
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- 抗原 See all RFWD2 抗体
- RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))
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抗原表位
- Middle Region
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适用
- 人, 小鼠, 大鼠, Cow, 兔, 犬, 豚鼠, 马
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RFWD2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 序列
- MSGLYSPVSE DSTVPQFEAP SPSHSSIIDS TEYSQPPGFS GTSQTKKQPW
- 预测反应
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%
- 产品特性
- This is a rabbit polyclonal antibody against Rfwd2. It was validated on Western Blot.
- 纯化方法
- Affinity Purified
- Top Product
- Discover our top product RFWD2 Primary Antibody
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anti-Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) (AA 632-731) antibody
RFWD2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1E4 unconjugated
anti-Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) (Internal Region) antibodyRFWD2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) antibodyRFWD2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) (Tyr762) antibodyRFWD2 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) (AA 301-350) antibodyRFWD2 适用: 人, 小鼠, Cow, 兔, 犬, 豚鼠, 马, Pig, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) (AA 582-731) antibodyRFWD2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) (AA 37-65), (N-Term) antibodyRFWD2 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB19572 unconjugated
anti-Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2) (AA 672-701), (C-Term) antibodyRFWD2 适用: 人 WB 宿主: 兔 Polyclonal RB41831 unconjugated
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- 应用备注
- Optimal working dilutions should be determined experimentally by the investigator.
- 说明
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Antigen size: 733 AA
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze-thaw cycles.
- 储存条件
- -20 °C
- 储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- 抗原
- RFWD2 (Ring Finger and WD Repeat Domain 2, E3 Ubiquitin Protein Ligase (RFWD2))
- 别名
- Rfwd2 (RFWD2 产品)
- 别名
- COP1 antibody, RNF200 antibody, AI316802 antibody, C80879 antibody, Cop1 antibody, RGD1304773 antibody, RFWD2 antibody, cop1 antibody, rnf200 antibody, zgc:163067 antibody, ring finger and WD repeat domain 2 antibody, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase antibody, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase L homeolog antibody, RFWD2 antibody, Rfwd2 antibody, rfwd2 antibody, rfwd2.L antibody
- 背景
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Rfwd2 is an E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It is involved in JUN ubiquitination and degradation and directly involved in p53 (TP53) ubiquitination and degradation, thereby abolishing p53-dependent transcription and apoptosis. Ubiquitinates p53 independently of MDM2 or RCHY1. Rfwd2 probably mediates E3 ubiquitin ligase activity by functioning as the essential RING domain subunit of larger E3 complexes. In contrast, it does not constitute the catalytic RING subunit in the DCX DET1-COP1 complex that negatively regulates JUN, the ubiquitin ligase activity being mediated by RBX1.
Alias Symbols: AI316802, C80879, Cop1
Protein Interaction Partner: CRY2, Reg1, Ptpn11, Fasn, Trib3, Trib2, Trib1,
Protein Size: 733 - 分子量
- 80 kDa
- 基因ID
- 26374
- NCBI登录号
- NM_011931, NP_036061
- UniProt
- Q9R1A8
- 途径
- Photoperiodism
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