FHL2 抗体
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- 抗原 See all FHL2 抗体
- FHL2 (Four and A Half LIM Domains 2 (FHL2))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FHL2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 人
- 产品特性
- Four-and-a-half LIM only protein 2, FHL2,Sphingosine kinase-1 (SK1) is a key enzyme that catalyzes the phosphorylation of sphingosine to sphingosine-1-phosphate (S1P). SK1, and its product S1P, regulate numerous and diverse biological functions, including cell growth, differentiation, proliferation, and apoptosis. S1P also plays a central role in cardiac development and ischemic preconditioning. FHL2 (SLIM3) has been identified as a SK1-interacting protein in mammalian cardiomyocytes. FHL2, but not FHL1 or FHL3, interacts with SK1, and FHL2 colocalizes with SK1 in the cytoplasm of these cells. The interaction of FHL2 with SK-1 involves the C-terminal portion of SK1. Overexpression of FHL2 has been found to attneuate the activity and antiapoptotic effects of SK1. Endothelin-1, a potent survival factor in cardiomyocytes, inhibits FHL2-SK1 association and increases SK1 activity. FHL2 is therefore a novel inhibitor of SK1 activity in cardiomyocytes and targeting FHL2 may prevent myocardial apoptosis through activation of SK1. A transcriptional coactivator, FHL2 is also known to form complexes consisting of Proline-, glutamic acid-, and leucine-rich protein-1 (PELP1), FHL2, and androgen receptors (AR) in prostate cancer cells, perhaps functioning as a molecular adaptor with PELP1 in the progression of prostate cancer.
- 纯化方法
- Antigen Immunoaffiinity Purification
- 免疫原
- Synthetic peptide derived from the human FHL2 protein
- 亚型
- IgG
- Top Product
- Discover our top product FHL2 Primary Antibody
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anti-Four and A Half LIM Domains 2 (FHL2) (AA 1-279) antibody
FHL2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) antibodyFHL2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (AA 1-279) antibodyFHL2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2G3-1A5 unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (AA 112-233) antibodyFHL2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (AA 199-248) antibodyFHL2 适用: 人, 小鼠, 大鼠, 犬, 马, 斑马鱼, 猴, Bat, Hamster, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) antibodyFHL2 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (C-Term) antibodyFHL2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) antibodyFHL2 适用: 人, 小鼠 WB, IHC (p), IP 宿主: 小鼠 Monoclonal 31-10-34 unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (C-Term) antibodyVerified FHL2 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Four and A Half LIM Domains 2 (FHL2) (AA 182-231) antibodyFHL2 适用: 人, Cow, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Antibody can be used for Western blotting (0.5-2 μg/mL). Also binds ABB73038, FHL2 isoform 5 with MW of 389 a.a. (~42 kDa). Optimal concentration should be evaluated by serial dilutions.
- 限制
- 仅限研究用
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- 浓度
- Lot specific
- 缓冲液
- Provided as ligand affinity purified antibody in phosphate buffered saline with 0.08 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -80 °C
- 储存方法
- Product should be stored at -70°C. Aliquot to avoid freeze/thaw cycles
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- 抗原
- FHL2 (Four and A Half LIM Domains 2 (FHL2))
- 别名
- FHL2 (FHL2 产品)
- 别名
- AAG11 antibody, DRAL antibody, FHL-2 antibody, SLIM-3 antibody, SLIM3 antibody, C76204 antibody, FHL2 antibody, zgc:92428 antibody, zgc:103466 antibody, four and a half LIM domains 2 antibody, four and a half LIM domains 2a antibody, four and a half LIM domains 2b antibody, FHL2 antibody, Fhl2 antibody, fhl2 antibody, fhl2a antibody, fhl2b antibody
- 途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha
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