TANK 抗体
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- 抗原 See all TANK 抗体
- TANK (TRAF Family Member-Associated NFKB Activator (TANK))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TANK antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects endogenous levels of TANK protein. (region surrounding Phe194)
- 交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product TANK Primary Antibody
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anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 131-369) antibody
TANK 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 4-98) antibodyTANK 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (Internal Region) antibodyTANK 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 1-119) antibodyTANK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 88-114) antibodyTANK 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22057 unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (Center) antibodyTANK 适用: 人, 小鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (C-Term) antibodyTANK 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) antibodyTANK 适用: 人, 兔, Cow, 马, Pig, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) antibodyTANK 适用: 人, 小鼠, 大鼠, 兔, Cow, 马, 犬, 豚鼠, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) antibodyTANK 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 15 mM Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- TANK (TRAF Family Member-Associated NFKB Activator (TANK))
- 别名
- TANK / ITRAF (TANK 产品)
- 别名
- I-TRAF antibody, ITRAF antibody, TRAF2 antibody, C86182 antibody, E430026L09Rik antibody, zgc:153048 antibody, i-traf antibody, tank antibody, traf2 antibody, TRAF family member associated NFKB activator antibody, TRAF family member-associated Nf-kappa B activator antibody, TRAF family member-associated NFKB activator antibody, TRAF family member associated NFKB activator L homeolog antibody, TANK antibody, Tank antibody, tank antibody, tank.L antibody
- 背景
- The tumor necrosis factor (TNF) receptor superfamily is composed of several type I integral membrane glycoproteins that exhibit homology in their cystine- rich extracellular domains. Members of this family include TNF-RI and -RII, FAS, OX40, CD27, CD30 and CD40. Ligands for these receptors can be small, secreted proteins such as TNF, or type II integral membrane proteins, such as the CD40 ligand, CD40L. While the signal transduction mechanism of the TNF receptor superfamily is poorly understood, stimulation of cells with either TNF or soluble CD40L has been shown to induce the nuclear translocation of NFκB. Members of the TRAF family associate with activated TNF-R and CD40 and have been implicated in this process. The discovery of a novel protein, designated TANK, has shed light on the means by which TRAF activation of NFkB occurs. TANK is not only capable of binding to all three TRAFs, but also of synergizing with TRAF2 to activate the NFκB signaling cascade. TANK contains a regulatory carboxy terminal domain that maintains its inactivity in unstimulated cells. Upon its association with TRAF2, the inhibitory effect of this domain is overcome.Synonyms: I-TRAF, TRAF family member-associated NF-kappa-B activator, TRAF-interacting protein, TRAF2
- 分子量
- approx. 48 kDa
- 基因ID
- 10010
- NCBI登录号
- NP_001186064
- UniProt
- Q92844
- 途径
- p53 Pathway, TLR signaling, Activation of Innate immune Response
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