TANK 抗体 (Internal Region)
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- 抗原 See all TANK 抗体
- TANK (TRAF Family Member-Associated NFKB Activator (TANK))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TANK antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- I-TRAF Antibody detects endogenous levels of total I-TRAF.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human I-TRAF, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product TANK Primary Antibody
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anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 131-369) antibody
TANK 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 4-98) antibodyTANK 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 1-119) antibodyTANK 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (AA 88-114) antibodyTANK 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22057 unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (Center) antibodyTANK 适用: 人, 小鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (C-Term) antibodyTANK 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) antibodyTANK 适用: 人, 兔, Cow, 马, Pig, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) antibodyTANK 适用: 人, 小鼠, 大鼠, 兔, Cow, 马, 犬, 豚鼠, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TRAF Family Member-Associated NFKB Activator (TANK) (N-Term) antibodyTANK 适用: 人 WB, IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- TANK (TRAF Family Member-Associated NFKB Activator (TANK))
- 别名
- TANK (TANK 产品)
- 别名
- I-TRAF antibody, ITRAF antibody, TRAF2 antibody, C86182 antibody, E430026L09Rik antibody, zgc:153048 antibody, i-traf antibody, tank antibody, traf2 antibody, TRAF family member associated NFKB activator antibody, TRAF family member-associated Nf-kappa B activator antibody, TRAF family member-associated NFKB activator antibody, TRAF family member associated NFKB activator L homeolog antibody, TANK antibody, Tank antibody, tank antibody, tank.L antibody
- 背景
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Description: Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
Gene: TANK
- 分子量
- 47 kDa
- 基因ID
- 10010
- UniProt
- Q92844
- 途径
- p53 Pathway, TLR signaling, Activation of Innate immune Response
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