CYP17A1 抗体
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- 抗原 See all CYP17A1 抗体
- CYP17A1 (Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CYP17A1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- The antibody detects endogenous levels of CYP17A1 protein. (region surrounding asn249)
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product CYP17A1 Primary Antibody
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anti-Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) (AA 24-65) antibody
CYP17A1 适用: 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) (AA 1-508) antibodyCYP17A1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) (Internal Region) antibodyCYP17A1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) (AA 24-508) antibodyCYP17A1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) (AA 201-507) antibodyCYP17A1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) (AA 201-507) antibodyCYP17A1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) antibodyCYP17A1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Monoclonal 5A9 unconjugated Recombinant Antibody
anti-Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) (Center) antibodyCYP17A1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) (Internal Region) antibodyVerified CYP17A1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1) (AA 209-508) antibodyCYP17A1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. Immunohistochemistry: 1: 50approx. 1: 200. Immunofluorescence: 1: 50-1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- CYP17A1 (Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 (CYP17A1))
- 别名
- CYP17A1 (CYP17A1 产品)
- 别名
- cyp17 antibody, CYPXVII antibody, P450c17 antibody, cyp17a1 antibody, P450-C17 antibody, wu:fi13g04 antibody, wu:fi17b11 antibody, wu:fi31c08 antibody, zgc:136516 antibody, zgc:66494 antibody, P45017A1 antibody, CYP17 antibody, CPT7 antibody, P450C17 antibody, S17AH antibody, Cyp17 antibody, p450c17 antibody, cytochrome P450 17A1 antibody, cytochrome P450, family 17, subfamily A, polypeptide 1 antibody, steroidogenic cytochrome P450 17-hydroxylase/lyase antibody, cytochrome P450 family 17 subfamily A member 1 L homeolog antibody, cytochrome P450 family 17 subfamily A member 1 antibody, cytochrome P-450 17 alpha-hydroxylase/C17,20-lyase antibody, cytochrome P450, family 17, subfamily a, polypeptide 1 antibody, cytochrome P450c17 antibody, CpipJ_CPIJ010537 antibody, CpipJ_CPIJ010543 antibody, PTRG_02047 antibody, cyp17a1 antibody, cyp17 antibody, cyp17a1.L antibody, CYP17A1 antibody, Cyp17a1 antibody
- 背景
- The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies, such as CYP1A, CYP2A, CYP2C, CYP2D, CYP4A14, CYP7A, CYP7B, CYP8B, CYP11A, CYP17A1,CYPI9 and CYP27A, based on sequence similarities. CYP17A (17α-hydroxylase/17,20-lyase) is important for the conversion of pregnenolone and progesterone to dehydroepiandrosterone (DHEA) and androstenedione. In this process, it catalyzes both the 17α-hydroxylation and the 17,20-lyase reaction.CYP17A1 is crucial during sexual development, both during fetal development and during puberty, and is intracellularly regulated by cAMP levels. Defects in the CYP17A1 gene, which encodes for the protein, may cause adrenal hyperplasia type V (AH-V) which is characterized by hypokalemia and hypertension.Male patients affected by AH-V do not undergo normal sexual differentiation and develop female external genitalia and do not undergo pubertal develoment.Synonyms: 20 lyase, CYP17, CYPXVII, Cytochrome P450 17A1, P450-C17, P450c17, S17AH, Steroid 17-alpha-hydroxylase/17, Steroid 17-alpha-monooxygenase
- 分子量
- approx. 57 kDa
- 基因ID
- 1586
- NCBI登录号
- NP_000093
- UniProt
- P05093
- 途径
- Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin
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