GTF3C2 抗体
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- 抗原 See all GTF3C2 抗体
- GTF3C2 (General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GTF3C2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of TFIIIC110 protein. (region surrounding Arg95)
- 交叉反应 （详细）
- Species reactivity (tested):Human.
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
- 纯度
- > 95 % pure by SDS-PAGE
- Top Product
- Discover our top product GTF3C2 Primary Antibody
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anti-General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2) antibody
GTF3C2 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2) (N-Term) antibodyGTF3C2 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2) (AA 1-911) antibodyGTF3C2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2) (AA 1-911) antibodyGTF3C2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1C6-2B8 unconjugated
anti-General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2) (AA 1-911) antibodyGTF3C2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2) antibodyGTF3C2 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2) (N-Term) antibodyGTF3C2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2) (AA 755-804) antibodyGTF3C2 适用: 人, Cow, 豚鼠, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1,0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- DO NOT FREEZE!
- 储存条件
- 4 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C.
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- 抗原
- GTF3C2 (General Transcription Factor IIIC, Polypeptide 2, beta 110kDa (GTF3C2))
- 别名
- GTF3C2 / TFIIIC110 (GTF3C2 产品)
- 别名
- TFIIIC110 antibody, GTF3C2 antibody, MGC155253 antibody, TF3C-beta antibody, DKFZp469M0113 antibody, 1300004C11Rik antibody, 2610510G03Rik antibody, AI225816 antibody, AU041069 antibody, mKIAA0011 antibody, TFIIIC-BETA antibody, general transcription factor IIIC subunit 2 antibody, general transcription factor IIIC, polypeptide 2, beta antibody, Gtf3c2 antibody, GTF3C2 antibody
- 背景
- RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB", the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.Synonyms: General transcription factor 3C polypeptide 2, KIAA0011, TF3C-beta, Transcription factor IIIC 110 kDa subunit, Transcription factor IIIC subunit beta
- 分子量
- approx. 100 kDa
- 基因ID
- 2976
- NCBI登录号
- NP_001030598
- UniProt
- Q8WUA4
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