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P-Selectin 抗体

SELP 适用: 小鼠 FACS, IP, ELISA, IHC (fro), IHC (p), BR, IHC (f) 宿主: 大鼠 Monoclonal RB40-34 unconjugated
产品编号 ABIN2689366
发货至: 中国
  • 抗原 See all P-Selectin (SELP) 抗体
    P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))
    适用
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    小鼠
    宿主
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    大鼠
    克隆类型
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    单克隆
    标记
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    This P-Selectin antibody is un-conjugated
    应用范围
    • 81
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    Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Blocking Reagent (BR), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    品牌
    BD Pharmingen™
    产品特性
    The RB40.34 antibody reacts with mouse P-selectin (CD62P), a 140 kDa protein which is expressed on activated platelets, activated endothelial cells, and megakaryocytes. P-selectin mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells, mediates leukocyte rolling, and is involved in the migration of leukocytes into inflamed tissues. CD24 and CD162 (PSGL-1) are ligands of CD62P. mAb RB40.34 can block mouse P-selectin binding to its ligands in vitro and in vivo. Immunohistochemical staining of megakaryocytes and platelets. The frozen section of normal mouse spleen was reacted with RB40.34 mAb. Megakaryocytes and platelets are identified by the intense brown staining.

    BD Pharmingen™ Purified Rat Anti-Mouse CD62P - Purified - Clone RB40.34 - Isotype Rat IgG1, λ - Reactivity Ms - 1 mL
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    P-selectin-IgG1 Fusion
    克隆位点
    RB40-34
    亚型
    IgG1 lambda
    Top Product
    Discover our top product SELP Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    31.25 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, goat serum, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4°C.
  • Yang, Galipeau, Kozak, Furie, Furie: "Mouse P-selectin glycoprotein ligand-1: molecular cloning, chromosomal localization, and expression of a functional P-selectin receptor." in: Blood, Vol. 87, Issue 10, pp. 4176-86, (1996) (PubMed).

    Aigner, Ruppert, Hubbe, Sammar, Sthoeger, Butcher, Vestweber, Altevogt: "Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin." in: International immunology, Vol. 7, Issue 10, pp. 1557-65, (1996) (PubMed).

    Ley, Bullard, Arbonés, Bosse, Vestweber, Tedder, Beaudet: "Sequential contribution of L- and P-selectin to leukocyte rolling in vivo." in: The Journal of experimental medicine, Vol. 181, Issue 2, pp. 669-75, (1995) (PubMed).

  • 抗原
    P-Selectin (SELP) (Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) (SELP))
    别名
    CD62P (SELP 产品)
    别名
    PSELECT antibody, CD62 antibody, CD62P antibody, GMP140 antibody, GRMP antibody, LECAM3 antibody, PADGEM antibody, PSEL antibody, GMP-140 antibody, Grmp antibody, selectin P antibody, selectin, platelet antibody, Selp antibody, SELP antibody
    背景
    Synonyms: P-selectin
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