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- 抗原 See all ICOS 抗体
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ICOS antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS)
- 品牌
- BD Pharmingen™
- 产品特性
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Monoclonal antibody DX29 reacts with inducible costimulatory (ICOS) molecule. ICOS is a homodimeric membrane glycoprotein, member of the CD28 family, of approximately 50 - 60 kDa, highly expressed on activated T cells. It is the receptor for B7 related protein 1 (B7RP-1) and also, like CD28, ICOS is costimulatory signal for T cell activation, proliferation and cytokine production. It is not expressed on resting or activated B cells, monocytes, NK cells, granulocytes, dendritic cells or platelets. Unlike the constitutively expressed CD28, ICOS expression is de novo. Reports describe similarities of CD28 and ICOS in T cell activation, however, it has been suggested that ICOS may play an important role in IL-10 production. In presence IL-10, purified recombinant human ICOS significantly increased in vitro B cell growth stimulated by pokeweed mitogen (PWM) and enhanced production of IgG. Profile of ICOS (DX29) reactivity on PHA-stimulated peripheral blood mononuclear cells analyzed by flow cytometry. Second step staining with Cat. No. 555988.
BD Pharmingen™ Purified Mouse Anti-Human CD278 - Purified - Clone DX29 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Activated human T cells
- 克隆位点
- DX29
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product ICOS Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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Regulation of immune and autoimmune responses by ICOS." in: Journal of autoimmunity, Vol. 21, Issue 3, pp. 255-60, (2003) (PubMed).
: "PI3-kinase and MAP-kinase signaling cascades in AILIM/ICOS- and CD28-costimulated T-cells have distinct functions between cell proliferation and IL-10 production." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 691-702, (2003) (PubMed).
: "AILIM/ICOS: its expression and functional analysis with monoclonal antibodies." in: Hybridoma and hybridomics, Vol. 20, Issue 5-6, pp. 293-303, (2002) (PubMed).
: "Characterization of human inducible costimulator ligand expression and function." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 9, pp. 4689-96, (2000) (PubMed).
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Regulation of immune and autoimmune responses by ICOS." in: Journal of autoimmunity, Vol. 21, Issue 3, pp. 255-60, (2003) (PubMed).
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- 抗原
- ICOS (Inducible T-Cell Co-Stimulator (ICOS))
- 别名
- CD278 (ICOS 产品)
- 别名
- ICOS antibody, AILIM antibody, CCLP antibody, CRP-1 antibody, H4 antibody, Ly115 antibody, CD278 antibody, CVID1 antibody, Ailim antibody, inducible T-cell costimulator antibody, inducible T cell co-stimulator antibody, inducible T-cell co-stimulator antibody, ICOS antibody, LOC100232284 antibody, Icos antibody
- 背景
- Synonyms: ICOS
- 途径
- Cancer Immune Checkpoints
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