(4 references)-
- 抗原 See all IL7R 抗体
- IL7R (Interleukin 7 Receptor (IL7R))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IL7R antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS)
- 品牌
- BD Pharmingen™
- 产品特性
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Monoclonal antibody hIL-7R-M21 reacts with the 60 - 90 kDa glycoprotein, CD127. CD127 is also known as the IL-7 receptor alpha (IL-7Rα). The receptor is a heterodimer composed of the CD127 and the common gamma chain, shared by other cytokine receptors (IL-2R, IL-4R, IL-9R, and IL-15R). CD127 is expressed on thymocytes, T- and B-cell progenitors, mature T cells, and some lymphoid and myeloid cells. In vitro experiments show the expression of CD127 is down-regulated following T cell activation. Studies indicate that the IL-7 Receptor plays an important role in the proliferation and differentiation of mature T cells. Recently, it has been shown that low surface expression of CD127, in combination with intermediate to high suface expression of CD25, the α chain of the IL-2 receptor, can distinguish between human regulatory and conventional CD4+ T cells in human adult and cord blood, lymph nodes and thymus. Profile of CD127 expression on peripheral blood lymphocytes analyzed by flow cytometry. Second step staining with Cat. No. 555988.
BD Pharmingen™ Purified Mouse Anti-Human CD127 - Purified - Clone HIL-7R-M21 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 克隆位点
- HIL-7R
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product IL7R Primary Antibody
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anti-Interleukin 7 Receptor (IL7R) (AA 173-260) antibody
IL7R 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 7 Receptor (IL7R) (AA 21-239) antibodyIL7R 适用: 人 FACS, WB, ELISA, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 3F5D9 unconjugated
anti-Interleukin 7 Receptor (IL7R) (AA 21-239) antibodyIL7R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 7 Receptor (IL7R) (AA 21-236) antibodyIL7R 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal IL7R-2751 unconjugated
anti-Interleukin 7 Receptor (IL7R) (N-Term) antibodyIL7R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 7 Receptor (IL7R) (pTyr449) antibodyIL7R 适用: 小鼠 WB, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 7 Receptor (IL7R) (pTyr449) antibodyIL7R 适用: 人 FACS, WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 7 Receptor (IL7R) antibody (APC)IL7R 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal A7R34 APC
anti-Interleukin 7 Receptor (IL7R) antibodyIL7R 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 7 Receptor (IL7R) (Ser552) antibodyIL7R 适用: 人, 小鼠, 猴 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "Lymphoid development from hematopoietic stem cells." in: International journal of hematology, Vol. 69, Issue 4, pp. 217-26, (1999) (PubMed).
: "Biological and clinical implications of interleukin-7 and lymphopoiesis." in: Cytokines, cellular & molecular therapy, Vol. 5, Issue 1, pp. 25-39, (1999) (PubMed).
: "Interleukin-7: physiological roles and mechanisms of action." in: Cytokine & growth factor reviews, Vol. 10, Issue 1, pp. 41-60, (1999) (PubMed).
: "Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily." in: Cell, Vol. 60, Issue 6, pp. 941-51, (1990) (PubMed).
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: "Lymphoid development from hematopoietic stem cells." in: International journal of hematology, Vol. 69, Issue 4, pp. 217-26, (1999) (PubMed).
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- 抗原
- IL7R (Interleukin 7 Receptor (IL7R))
- 别名
- CD127 (IL7R 产品)
- 别名
- IL7R antibody, CD127 antibody, IL-7Ralpha antibody, CDW127 antibody, IL-7R-alpha antibody, IL7RA antibody, ILRA antibody, IL-7RA antibody, interleukin 7 receptor antibody, IL7R antibody, Il7r antibody
- 背景
- Synonyms: Interleukin-7 receptor alpha
- 途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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