Nanog 抗体
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- 抗原 See all Nanog (NANOG) 抗体
- Nanog (NANOG) (Nanog Homeobox (NANOG))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Nanog antibody is un-conjugated
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应用范围
- Biochemical Assay (BCA)
- 纯化方法
- The antibody was purified by affinity chromatography.
- 克隆位点
- 16H3A48
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product NANOG Primary Antibody
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 浓度
- 0.5 mg/mL
- 缓冲液
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Upon receipt, store undiluted at 4°C
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- 抗原
- Nanog (NANOG) (Nanog Homeobox (NANOG))
- 别名
- Nanog (NANOG 产品)
- 别名
- 2410002E02Rik antibody, ENK antibody, ecat4 antibody, NANOG antibody, hacp antibody, wu:fd19e04 antibody, wu:fd20a07 antibody, zgc:193933 antibody, Nanog homeobox antibody, nanog homeobox antibody, Nanog antibody, NANOG antibody, nanog antibody
- 背景
- NANOG is a homeodomain-containing transcription factor that is essential for early embryonic development. It is primarily expressed in pluripotent embryonic stem (ES) cells and cancer cell lines, maintaining undifferentiated statuses of the cells and is downregulated upon differentiation. Si-RNA mediated knockdown of NANOG in ES cells induces lineage differentiation. Overexpression of NANOG allows for the leukemia inhibitory factor (LIF)-independent selfrenewal in undifferentiated ES cells. Nanog functionally works with OCT4 and SOX2 to support pluripotency and selfrenewal in ES cells and the expression of NANOG is regulated by OCT4/SOX2 heterodimers. Expression of NANOG has been detected in several types of tumor cells. The expression level of NANOG in cancer cells has been shown to be correlated with the malignancy of cancers.
- 途径
- Stem Cell Maintenance
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