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CD28 抗体

CD28 适用: 人 BCA 宿主: 小鼠 Monoclonal CD28-2 unconjugated
产品编号 ABIN2664495
发货至: 中国
  • 抗原 See all CD28 抗体
    CD28
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This CD28 antibody is un-conjugated
    应用范围
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    Biochemical Assay (BCA)
    交叉反应
    Chimpanzee, Baboon, Cynomolgus, 猕猴, Pigtailed Macaque, Capuchin Monkey, Sooty mangabey (Cercocebus atys), Squirrel Monkey (Saimiri spec.)
    纯化方法
    The antibody was purified by affinity chromatography.
    克隆位点
    CD28-2
    亚型
    IgG1 kappa
    Top Product
    Discover our top product CD28 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and EDTA.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    CD28
    别名
    CD28 (CD28 产品)
    别名
    Tp44 antibody, CD28RNA antibody, cd28 antibody, CD28 molecule antibody, CD28 antigen antibody, Cd28 molecule antibody, CD28 molecule L homeolog antibody, CD28 antibody, Cd28 antibody, cd28.L antibody
    背景
    CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.
    途径
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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