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FCER2 抗体 (PE)

FCER2 适用: 人 FACS, ICFC 宿主: 小鼠 Monoclonal EBVCS-5 PE
产品编号 ABIN2663197
发货至: 中国
  • 抗原 See all FCER2 抗体
    FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))
    适用
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    宿主
    • 55
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    小鼠
    克隆类型
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    单克隆
    标记
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    This FCER2 antibody is conjugated to PE
    应用范围
    • 69
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    Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)
    纯化方法
    The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
    克隆位点
    EBVCS-5
    亚型
    IgG1 kappa
    Top Product
    Discover our top product FCER2 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Protect from prolonged exposure to light. Do not freeze.
    储存条件
    4 °C
    储存方法
    The antibody solution should be stored undiluted between 2°C and 8°C.
  • 抗原
    FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))
    别名
    CD23 (FCER2 产品)
    别名
    BLAST-2 antibody, CD23 antibody, CD23A antibody, CLEC4J antibody, FCE2 antibody, IGEBF antibody, Fcer2a antibody, Fc fragment of IgE receptor II antibody, FCER2 antibody, Fcer2 antibody
    背景
    CD23 is a 45 kD protein, also known as Leu-20, FcεRII, IgE Fc receptor, BLAST-2, B6, and low affinity IgE receptor. It is a member of the Ig family, expressed on most mature B cells, B cells in follicular mantle (but not in proliferating germinal center cells, follicular dendritic cells, monocytes, eosinophils, Langerhans cells, and a subset of T cells (10-15 % of tonsillar T cells). CD23 responds to high levels of IgE by downregulating IgE secretion. In human monocytes, CD23 triggering results in release of pro-inflammatory cytokines including TNF-α, IL-1, IL-6, and GM-CSF. CD23 can be proteolytically cleaved to generate soluble CD23 fragments of various molecular weights. In chronic lymphocytic leukemia, levels of soluble CD23 in the serum can be used as a prognostic marker to identify patients at high risk for disease progression. Alternate splicing of exon 2 can also generate two cell-surface isoforms of CD23 differing by 6 amino acids in their cytoplasmic region.
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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