ATF2 抗体
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- 抗原 See all ATF2 抗体
- ATF2 (Activating Transcription Factor 2 (ATF2))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ATF2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects endogenous levels of ATF2 protein. (region surrounding Gly56)
- 交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity Chromatography using epitope-specific immunogen
- Top Product
- Discover our top product ATF2 Primary Antibody
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anti-Activating Transcription Factor 2 (ATF2) (AA 1-190) antibody
ATF2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (pThr51), (pThr69) antibodyATF2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (pSer44), (pSer62) antibodyATF2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (pThr53), (pThr71) antibodyATF2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (AA 93-450) antibodyATF2 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (C-Term) antibodyATF2 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (AA 93-450) antibodyATF2 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC (fro), FACS 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (pThr73) antibodyATF2 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 2 (ATF2) (AA 1-209) antibodyATF2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E12 unconjugated
anti-Activating Transcription Factor 2 (ATF2) (AA 91-190) antibodyATF2 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 1C2 unconjugated
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- 应用备注
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ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. IP: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- ATF2 (Activating Transcription Factor 2 (ATF2))
- 别名
- ATF2 (ATF2 产品)
- 背景
- The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2. Mutations of these sites result in the loss of stress-induced transcription by ATF-2. In addition, mutations at these sites reduce the ability of E1A and Rb to stimulate gene expression via ATF-2.Synonyms: ATF-2, Activating transcription factor 2, CRE-BP1, CREB-2, CREB2, CREBP1, Cyclic AMP-dependent transcription factor ATF-2, Cyclic AMP-responsive element-binding protein 2, HB16, cAMP response element-binding protein CRE-BP1, cAMP-dependent transcription factor ATF-2
- 分子量
- approx. 55 to 75 kDa
- 基因ID
- 1386
- NCBI登录号
- NP_001871
- UniProt
- P15336
- 途径
- MAPK Pathway, RTK signaling, Thyroid Hormone Synthesis, Activation of Innate immune Response, Chromatin Binding, Myometrial Relaxation and Contraction, Synaptic Membrane, Tube Formation, Toll-Like Receptors Cascades
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