TIRAP 抗体 (Middle Region)
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- 抗原 See all TIRAP 抗体
- TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))
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抗原表位
- Middle Region
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This TIRAP antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- This antibody reacts to TIRAP.
- 纯化方法
- Purified
- 免疫原
- Rabbit polyclonal TIRAP antibody was raised against a peptide corresponding to amino acids near the middle of human TIRAP.
- 亚型
- IgG
- Top Product
- Discover our top product TIRAP Primary Antibody
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anti-Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP) (AA 1-221) antibody
TIRAP 适用: 人 WB, ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP) (AA 1-221) antibodyTIRAP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP) (AA 1-221) antibodyTIRAP 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP) (AA 1-256) antibodyTIRAP 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP) antibodyTIRAP 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP) (N-Term) antibodyTIRAP 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP) (pTyr86) antibodyTIRAP 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Western Blot: 4 μg/mL. Found in the cytoplasm and highly expressed in liver, kidney, spleen, skeletal muscle andheart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine,thymus, colon and brain.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 缓冲液
- Phosphate buffered saline with 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.
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- 抗原
- TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))
- 别名
- TIRAP (TIRAP 产品)
- 别名
- mal antibody, wyatt antibody, BACTS1 antibody, Mal antibody, MyD88-2 antibody, AA407980 antibody, C130027E04Rik antibody, Tlr4ap antibody, Wyatt antibody, toll-interleukin 1 receptor (TIR) domain containing adaptor protein antibody, TIR domain containing adaptor protein antibody, toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog antibody, toll-interleukin 1 receptor (TIR) domain-containing adaptor protein antibody, tirap antibody, TIRAP antibody, tirap.L antibody, Tirap antibody
- 背景
- Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1 - 3). These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors (4,5). In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling (6). Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-kappaB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling (6,7)Synonyms: Adaptor protein Wyatt, MAL, MyD88 adapter-like protein, TIR domain-containing adapter protein, Toll/interleukin-1 receptor domain-containing adapter protein
- 基因ID
- 114609
- NCBI登录号
- NP_001034750
- UniProt
- P58753
- 途径
- TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
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