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p53 抗体 (AA 371-380)

Name: p53 抗体 (AA 371-380)
SKU: ABIN264449
Availability: OutOfStock

TP53 适用: 人, 小鼠, 大鼠, 猴 WB, IP, IHC (fro), EIA 宿主: 小鼠 Monoclonal HR231 unconjugated

Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) (AA 371-380) antibody (ABIN264449) (p53 抗体 (AA 371-380))

2 images

产品编号 ABIN264449

发货至: 中国

Datasheet as PDF

抗原 See all p53 (TP53) 抗体

p53 (TP53) (Tumor Protein P53 (TP53))
抗原表位
51

41

40

39

32

30

28

25

24

24

23

20

20

20

18

18

16

16

14

13

9

9

9

9

9

9

8

7

7

7

7

7

6

6

6

6

5

5

5

4

4

4

3

3

3

3

3

3

3

3
AA 371-380
适用
888

268

219

109

45

34

31

18

10

8

8

6

4

4

3

2

2

2

2

2

1

1

1

1

1
人, 小鼠, 大鼠, 猴
宿主
676

227

6

2

1

1
小鼠
Compatible Secondaries
克隆类型
611

301

1
单克隆
标记
508

49

39

26

25

24

24

24

22

22

22

13

13

13

13

13

13

5

5

5

5

5

5

2

2

2

2

2

2

2

1

1

1

1

1

1
This p53 antibody is un-conjugated
应用范围
717

336

254

216

208

150

124

122

119

61

61

32

20

17

13

12

11

10

9

8

6

4

3

2

2

2

1

1

1

1

1
Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

特异性

This antibody reacts to p53.

交叉反应（详细）

Species reactivity (tested):Human, Monkey, Mouse and Rat.

产品特性

Synonyms: Cellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, NY-CO-13

纯化方法

Affinity chromatography on Protein A/G

免疫原

Hybridoma produced by the fusion of splenocytes from immunized with full length humanp53 protein and mouse myeloma cells.

克隆位点

HR231

亚型

IgG2b

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TP53 适用: 人 WB, ELISA, IHC (p), PLA, RNAi 宿主: 小鼠 Monoclonal 2C11 unconjugated

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anti-Tumor Protein P53 (TP53) (acLys319) antibody
TP53 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Western Blot (1-5 μg/mL). ELISA. Immunoprecipitation. Immunohistochemistry. Positive Control: Breast or colon carcinoma cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

1,0 mg/mL

缓冲液

PBS, 0.08 % Sodium Azide

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

有效期

12 months
抗原

p53 (TP53) (Tumor Protein P53 (TP53))

别名

p53 (TP53) (TP53 产品)

别名

BCC7 antibody, LFS1 antibody, P53 antibody, TRP53 antibody, p53 antibody, Trp53 antibody, brp53 antibody, drp53 antibody, etID22686.5 antibody, fb40d06 antibody, wu:fb40d06 antibody, zgc:111919 antibody, Tp53 antibody, bbl antibody, bfy antibody, bhy antibody, p44 antibody, tp53 antibody, Xp53 antibody, TP53 antibody, tumor protein p53 antibody, cellular tumor antigen p53 antibody, transformation related protein 53 antibody, tumor protein p53 L homeolog antibody, TP53 antibody, CpipJ_CPIJ002758 antibody, Tp53 antibody, tp53 antibody, Trp53 antibody, tp53.L antibody

背景

P53 is a 53 kDa transcription factor that can inhibit cell cycle progression or induce apoptosis in response to stress or DNA damage. Disruption of the p53 signalling pathway through various mechanisms is the most common alteration in human cancer occuring in over half of all tumors. The p53 protein is short lived and expressed at low levels in normal cells but accumulates and/or is activated in cells that have undergone genotoxic damage or oncogene activation. Many tumor derived and transformed cell lines express elevated levels of mutant p53 protein. Other genes also implicated in the downstream effects as a result of p53 activation are: p21WAF1, GADD45, 14-3-3, bax, Fas/APO1, KILLER/ DR5, Tsp1, IGF-BP3 and others.Synonyms: Cellular tumor antigen p53, NY-CO-13, Phosphoprotein p53, Tumor suppressor p53

基因ID

7157

UniProt

P04637

途径

p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect