SGK1 抗体 (AA 211-431)
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Quick Overview for SGK1 抗体 (AA 211-431) (ABIN2468035)
抗原
See all SGK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 211-431
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纯化方法
- Immunoaffinity Purified
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应用备注
- Serine/threonine-protein kinase Sgk1 antibody can be used for the detection of Serine/threonine-protein kinase Sgk1 by Western Blot.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate-Buffered Saline. No preservatives added.
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储存液
- Without preservative
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注意事项
- As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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储存条件
- 4 °C/-20 °C
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储存方法
- SGK antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.
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- SGK1 (serum/glucocorticoid Regulated Kinase 1 (SGK1))
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别名
- SGK
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背景
- FUNCTION: Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, Kv1.3, or EAAT1.
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分子量
- 49 kDa (calculated)
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基因ID
- 6446
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NCBI登录号
- NP_005618
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UniProt
- O00141
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途径
- MAPK Pathway, Notch Signaling, Steroid Hormone Mediated Signaling Pathway
抗原
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