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Zona Pellucida Glycoprotein 3 抗体

ZP3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN2461230
发货至: 中国
  • 抗原 See all Zona Pellucida Glycoprotein 3 (ZP3) 抗体
    Zona Pellucida Glycoprotein 3 (ZP3)
    适用
    • 23
    • 3
    • 3
    • 2
    • 2
    • 2
    宿主
    • 21
    • 2
    克隆类型
    • 23
    多克隆
    标记
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    This Zona Pellucida Glycoprotein 3 antibody is un-conjugated
    应用范围
    • 21
    • 14
    • 3
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    Antibody is purified by protein A chromatography method.
    免疫原
    Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human ZP3.
    Top Product
    Discover our top product ZP3 Primary Antibody
  • 应用备注
    ZP3 antibody can be used for detection of ZP3 by ELISA at 1:62500. ZP3 antibody can be used for detection of ZP3 by western blot at 0.6 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
    浓度
    1 mg/mL
    缓冲液
    Antibody is lyophilized in PBS buffer with 2 % sucrose.
    注意事项
    As with any antibody avoid repeat freeze-thaw cycles.
    储存条件
    4 °C/-20 °C
    储存方法
    For short periods of storage (days) store at 4 °C. For longer periods of storage, store ZP3 antibody at -20 °C.
  • 抗原
    Zona Pellucida Glycoprotein 3 (ZP3)
    别名
    ZP3 (ZP3 产品)
    别名
    ZP3A antibody, ZP3B antibody, ZPC antibody, Zp-3 antibody, zp3.2 antibody, Zp-3B antibody, zona pellucida glycoprotein 3 antibody, zona pellucida sperm-binding protein 3 antibody, ZP3 antibody, zp3 antibody, Zp3 antibody
    背景
    The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene
    分子量
    47 kDa, 23 kDa
    基因ID
    7784
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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