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Zona Pellucida Glycoprotein 3 抗体

ZP3 适用: 人, 大鼠, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7256676
发货至: 中国
  • 抗原 See all Zona Pellucida Glycoprotein 3 (ZP3) 抗体
    Zona Pellucida Glycoprotein 3 (ZP3)
    适用
    • 22
    • 2
    • 2
    • 2
    • 2
    • 2
    人, 大鼠, 小鼠
    宿主
    • 20
    • 2
    克隆类型
    • 22
    多克隆
    标记
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    This Zona Pellucida Glycoprotein 3 antibody is un-conjugated
    应用范围
    • 21
    • 14
    • 2
    • 1
    Immunofluorescence (IF)
    产品特性
    Polyclonal Antibody
    纯化方法
    Affinity purification
    免疫原
    A synthetic peptide of human ZP3 (NP_001103824.1).
    亚型
    IgG
  • 应用备注
    IF 1:50-1:200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    Zona Pellucida Glycoprotein 3 (ZP3)
    别名
    ZP3 (ZP3 产品)
    别名
    ZP3A antibody, ZP3B antibody, ZPC antibody, Zp-3 antibody, zp3.2 antibody, Zp-3B antibody, zona pellucida glycoprotein 3 antibody, zona pellucida sperm-binding protein 3 antibody, ZP3 antibody, zp3 antibody, Zp3 antibody
    背景
    The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus, however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene.
    基因ID
    7784
    UniProt
    P21754
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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