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IL7R 抗体

IL7R 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN233846
发货至: 中国
  • 抗原 See all IL7R 抗体
    IL7R (Interleukin 7 Receptor (IL7R))
    适用
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    多克隆
    标记
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    This IL7R antibody is un-conjugated
    应用范围
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    Western Blotting (WB), ELISA
    交叉反应
    小鼠, 大鼠
    产品特性
    Concentration Definition: by UV absorbance at 280 nm
    免疫原
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminus of mouse IL-7 receptor protein.
    亚型
    IgG
    Top Product
    Discover our top product IL7R Primary Antibody
  • 应用备注
    This affinity purified antibody has been tested for use in ELISA and western blotting.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 55 kDa in size corresponding to IL-7 receptor protein by western blotting in the appropriate cell lysate or extract.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.82 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • 抗原
    IL7R (Interleukin 7 Receptor (IL7R))
    别名
    IL-7 Receptor Alpha Chain (IL7R 产品)
    别名
    IL7R antibody, CD127 antibody, IL-7Ralpha antibody, CDW127 antibody, IL-7R-alpha antibody, IL7RA antibody, ILRA antibody, IL-7RA antibody, interleukin 7 receptor antibody, IL7R antibody, Il7r antibody
    背景
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Interleukin-7 is a glycoprotein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules.  The human and mouse sequence is nearly identical.  In humans, severe combined immunodeficiency is caused by genetic defects in IL-7 receptor. The tyrosine residue at the 449 position is a critical signaling site of the intracellular domain of IL-7 receptor. This site is rapidly phosphorylated by janus kinases after the IL-7 receptor is engaged. IL-7 Receptor Alpha Chain Antibody is ideal for investigators interested in Immunology research.
    Synonyms: IL7R alpha antibody, Interleukin 7 receptor alpha chain antibody, Interleukin 7 receptor antibody
    基因ID
    16197, 45269152
    UniProt
    P16872
    途径
    JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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