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ICAM1 抗体 (Biotin)

ICAM1 适用: 人 FACS, IHC (p), IHC (fro), StM, IA 宿主: 小鼠 Monoclonal HM-2 Biotin
产品编号 ABIN2191982
发货至: 中国
  • 抗原 See all ICAM1 抗体
    ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
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    小鼠
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    单克隆
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    This ICAM1 antibody is conjugated to Biotin
    应用范围
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    Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Staining Methods (StM), Immunoassay (IA)
    过滤
    0.2 μm filtered
    克隆位点
    HM-2
    Top Product
    Discover our top product ICAM1 Primary Antibody
  • 应用备注
    For immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
    限制
    仅限研究用
  • 缓冲液
    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
    有效期
    12 months
  • van de Stolpe, van der Saag: "Intercellular adhesion molecule-1." in: Journal of molecular medicine (Berlin, Germany), Vol. 74, Issue 1, pp. 13-33, (1996) (PubMed).

    Sligh, Ballantyne, Rich, Hawkins, Smith, Bradley, Beaudet: "Inflammatory and immune responses are impaired in mice deficient in intercellular adhesion molecule 1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 18, pp. 8529-33, (1993) (PubMed).

  • 抗原
    ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))
    Abstract
    ICAM1 产品
    别名
    BB2 antibody, CD54 antibody, P3.58 antibody, Icam-1 antibody, Ly-47 antibody, MALA-2 antibody, ICAM antibody, ICAM-1 antibody, ICAM1 antibody, intercellular adhesion molecule 1 antibody, intercellular adhesion molecule-1 antibody, ICAM1 antibody, Icam1 antibody, ICAM-1 antibody
    背景
    The monclonal antibody HM.2 reacts with the 90 kD glycoprotein Intracellular Adhesion Molecule-1 (ICAM-1). The adhesion molecule ICAM-1 belongs to the immunoglobulin superfamily, C2 subset, it is a ligand for the Integrins LFA-1 and MAC-1 and for CD43. ICAM-1 is a essential component in many immune-related processes. ICAM-1 links with receptors of the integrin family, thereby mediating cell-cell interactions and allowing for signal transduction. ICAM-1 interacts specifically with its receptors to induce a reversible adhesion interaction. For processes like T cell activation and leucocyte recruitment, normal immune function relies on ICAM-1. Therefore, it is understandable that alterations in ICAM-1 structure or expression are associated with immune disorders. It is important to properly understand the various functions and regulatory mechanisms of ICAM-1, the resulting disease-related failures, and the various treatments. ICAM-1 is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFalpha) and is expressed by the vascular endothelium, macrophages and lymphocytes Aliases ICAM-1, CD54
    途径
    Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling
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