PDGF-BB Homodimer 抗体
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- 抗原
- PDGF-BB Homodimer
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB), ELISA, Functional Studies (Func)
- 特异性
- Recognizes human PDGF-BB (Platelet derived growth factor B chain), a disulphide-linked beta-chain homodimer and member of the PDGF family, released from platelet alpha-granules following trauma/platelet activation. Naturally occurring active forms of PDGF exist as dimers of two alpha chains (AA), two beta chains (BB), or a combination of both chains (AB), all of which signal through the high-affinity PDGF-Ralpha receptor, and the latter two of which can also signal through the PDGF-Rbeta receptor. PDGFs are potent mitogens for a variety of cells including those of the connective tissue, bone and cartilage, blood and smooth muscle cells, and are involved in several biological processes including chemotaxis, hyperplasia and embryonic neurogenesis. The expression of PDGF-BB is associated with autocrine growth stimulation and the formation of various tumor types, with several studies focusing on dermatofibrosarcoma protuberans (DP), an infiltrating skin tumor arising from a translocation occurring between chromosome 22 (the location of the PDGFB gene) and chromosome 17 (the location of the COL1A1 gene), which results in the generation of the COL1A1-PDGFB chimeric protein.
- 纯化方法
- Purified
- 免疫原
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Recombinant human PDGF-BB.
Type of Immunogen: Recombinant protein - 亚型
- IgG
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anti-PDGF-BB Homodimer (AA 151-241) antibody
适用: 人, 小鼠, 大鼠, 小鸡 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-PDGF-BB Homodimer (AA 82-190) antibody适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-PDGF-BB Homodimer (AA 21-241) antibody适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-PDGF-BB Homodimer (N-Term) antibody适用: 人, 小鼠, 大鼠, Cow, 绵羊, Bat, 犬, 豚鼠, 兔, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-PDGF-BB Homodimer (AA 82-190) antibody适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal 4# unconjugated
anti-PDGF-BB Homodimer (AA 5-225) antibody适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Approved: ELISA (0.5 μg/mL), Func (3 - 4 μg/mL), WB (0.1 - 0.2 μg/mL)
- 说明
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Target Species of Antibody: Human
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Distilled Water. For long term storage the addition of 0.09 % sodium azide is recommended. For functional studies do not add azide.
- 浓度
- Lot specific
- 缓冲液
- Lyophilized, PBS, pH 7.4.
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- 抗原
- PDGF-BB Homodimer
- 别名
- PDGF-BB
- 别名
- PDGF-2 antibody, PDGF2 antibody, SIS antibody, SSV antibody, c-sis antibody, PDGF-B antibody, Sis antibody, platelet derived growth factor subunit B antibody, platelet derived growth factor, B polypeptide antibody, PDGFB antibody, Pdgfb antibody
- 背景
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Name/Gene ID: PDGFB
Family: PDGF
Synonyms: PDGFB, Becaplermin, PDGF-BB, PDGF-b, SSV, PDGF subunit B, PDGF-2, PDGF2, Proto-oncogene c-Sis, SIS, C-sis, PDGF, B chain - 基因ID
- 5155
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