C5AR1 抗体 (AA 15-27) (PE)
(4 references)-
- 抗原 See all C5AR1 抗体
- C5AR1 (Complement Component 5a Receptor 1 (C5AR1))
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抗原表位
- AA 15-27
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适用
- 人, Cow, 兔, 雪貂
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This C5AR1 antibody is conjugated to PE
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The mouse monoclonal antibody S5/1 recognizes an extracellular epitope of CD88 protein, a 43 kDa receptor of C5a component of the complement cascade.
- 交叉反应 （详细）
- Human, Bovine, Ferret, Rabbit
- 纯化方法
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- 免疫原
- Recombinant N-terminal peptide (Asp15-Asp27) of human C5aR
- 克隆位点
- S5-1
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product C5AR1 Primary Antibody
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anti-Complement Component 5a Receptor 1 (C5AR1) (C-Term) antibody
Verified C5AR1 适用: 人 WB, FACS, ELISA, IHC, IF 宿主: 山羊 Polyclonal unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 1-350) antibodyC5AR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E2 unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 15-27) antibodyC5AR1 适用: 人, Cow, 兔, 雪貂 WB, FACS, IHC (p), IP 宿主: 小鼠 Monoclonal S5-1 unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 250-350) antibodyC5AR1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 1-36) antibodyC5AR1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) antibodyC5AR1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 1-350) antibodyC5AR1 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 1-350) antibodyC5AR1 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 5a Receptor 1 (C5AR1) (AA 15-27) antibody (FITC)C5AR1 适用: 人, Cow, 兔, 雪貂 FACS 宿主: 小鼠 Monoclonal S5-1 FITC
anti-Complement Component 5a Receptor 1 (C5AR1) (N-Term) antibodyC5AR1 适用: 人, Chimpanzee IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.
- 说明
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The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
- 限制
- 仅限研究用
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- 缓冲液
- Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
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Do not freeze. Avoid prolonged exposure to light.
Do not use after expiration date stamped on vial label.
Short-term exposure to room temperature should not affect the quality of the reagent. However, if reagent is stored under any conditions other than those specified, the conditions must be verified by the user. - 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
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: "Complement alternative pathway acts as a positive feedback amplification of neutrophil activation." in: Blood, Vol. 117, Issue 4, pp. 1340-9, (2011) (PubMed).
: "C5a mediates peripheral blood neutrophil dysfunction in critically ill patients." in: American journal of respiratory and critical care medicine, Vol. 180, Issue 1, pp. 19-28, (2009) (PubMed).
: "The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)." in: The Journal of biological chemistry, Vol. 277, Issue 9, pp. 7165-9, (2002) (PubMed).
: "Expression of the C5a receptor (CD88) on synovial mast cells in patients with rheumatoid arthritis." in: Arthritis and rheumatism, Vol. 41, Issue 2, pp. 233-45, (1998) (PubMed).
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: "Complement alternative pathway acts as a positive feedback amplification of neutrophil activation." in: Blood, Vol. 117, Issue 4, pp. 1340-9, (2011) (PubMed).
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- 抗原
- C5AR1 (Complement Component 5a Receptor 1 (C5AR1))
- 别名
- CD88 / C5aR (C5AR1 产品)
- 别名
- C5A antibody, C5AR antibody, C5R1 antibody, CD88 antibody, C5aR antibody, C5r1 antibody, Cd88 antibody, D7Msu1 antibody, GPR77 antibody, complement C5a receptor 1 antibody, complement component 5a receptor 1 antibody, C5AR1 antibody, C5ar1 antibody, c5ar1 antibody
- 背景
- Complement C5a receptor 1,CD88 / C5aR is a G protein-coupled seven membrane-spanning protein serving as a receptor for C5a component of the complement cascade, and is expressed mainly by monocytes, macrophages, neutrophils, eosinophils, and mast cells, but also e.g. by hepatocytes, glial cells, vascular endothelial cells, or cardiomyocytes. The binding of C5a to CD88 is associated with inflammatory response, including superoxide anion production, chemotaxis, and increased production of acute phase proteins. Expression of CD88 on synovial mast cells and their C5a-mediated degranulation plays a role in pathogenesis of rheumatoid arthritis.,C5A, C5R1, C5AR1
- 基因ID
- 728
- UniProt
- P21730
- 途径
- Complement System
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