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CDKN2A 抗体 (C-Term)

Name: CDKN2A 抗体 (C-Term)
SKU: ABIN1981278
Availability: OutOfStock

This anti-CDKN2A antibody is a 兔多克隆 antibody detecting CDKN2A in WB, IF, IHC (p) 和 FACS. Suitable for 人. This Primary Antibody has been cited in 1 publication.

Anti-CDKN2A Antibody (Center) at 1:2000 dilution + RI 8226 whole cell lysate Lysates/proteins at 20 μg per lane. (CDKN2A 抗体 (C-Term))

Immunohistochemical analysis of paraffin-embedded human epityphlon tissue using (ABIN1981278 and ABIN2845115) performed on the Leica® BOND RXm. (CDKN2A 抗体 (C-Term))

IHC (p)

Confocal immunofluorescent analysis of p16INK4a Antibody (C-term ) (ABIN1981278 and ABIN2845115) with Hela cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (CDKN2A 抗体 (C-Term))

Anti-p16INK4a Antibody (C-term ) at 1:2000 dilution + Hela whole cell lysate Lysates/proteins at 20 μg per lane. (CDKN2A 抗体 (C-Term))

Overlay histogram showing Hela cells stained with B(green line). (CDKN2A 抗体 (C-Term))

FACS

5 images

(1 reference)

产品编号 ABIN1981278

发货至: 中国

Datasheet as PDF

Quick Overview for CDKN2A 抗体 (C-Term) (ABIN1981278)

抗原

See all CDKN2A 抗体

CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

适用

人

宿主

兔

克隆类型

多克隆

标记

This CDKN2A antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

克隆位点

RB19093

抗原表位
2

2

2

1

1

1

1
AA 104-131, C-Term

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This p16INK4a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-131 amino acids from the C-terminal region of human p16INK4a.

亚型

Ig Fraction
anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) antibody
CDKN2A 适用: 人 WB, IF, IHC 宿主: 兔 Monoclonal unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (pSer140) antibody
CDKN2A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB21280 unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (AA 1-30), (N-Term) antibody
CDKN2A 适用: 人 WB 宿主: 兔 Polyclonal RB41435 unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (AA 145-176), (Ser152) antibody
CDKN2A 适用: 人 WB 宿主: 兔 Polyclonal RB53347 unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (pSer8) antibody
CDKN2A 适用: 人 DB 宿主: 兔 Polyclonal RB41435 unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (AA 39-65) antibody
CDKN2A 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (AA 1-30) antibody
CDKN2A 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (pSer8) antibody
CDKN2A 适用: 人 ELISA, DB 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (AA 39-65) antibody
CDKN2A 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40175 unconjugated

应用备注

IF: 1:10~50. WB: 1:2000. WB: 1:2000. IHC-P-Leica: 1:500. FC: 1:25

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

有效期

6 months
Han, Li, Zhang, Qin, Yang, Wang, Yuan, Xia: "Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells." in: International journal of oncology, Vol. 51, Issue 5, pp. 1439-1448, (2018) (PubMed).
抗原

CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

别名

p16INK4a

背景

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

分子量

16533

基因ID

1029

NCBI登录号

NP_000068, NP_001182061, NP_478104

UniProt

P42771

途径

Mitotic G1-G1/S Phases, Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Autophagy, Positive Regulation of Response to DNA Damage Stimulus