Caspase 9 抗体 (AA 299-318)
Quick Overview for Caspase 9 抗体 (AA 299-318) (ABIN1886865)
抗原
See all Caspase 9 (CASP9) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 299-318
-
交叉反应 (详细)
- It has no cross response to other members in caspase family.
-
纯化方法
- Affinity chromatography purified via peptide column
-
免疫原
- Peptide corresponding to amino acids 299 to 318 of human caspase-9.
-
-
-
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- PBS containing 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
-
注意事项
- Avoid freezing and thawing repeatly.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
-
-
-
Quercetin induces apoptosis via the mitochondrial pathway in KB and KBv200 cells." in: Journal of agricultural and food chemistry, Vol. 61, Issue 9, pp. 2188-95, (2013) (PubMed).
: "
-
Quercetin induces apoptosis via the mitochondrial pathway in KB and KBv200 cells." in: Journal of agricultural and food chemistry, Vol. 61, Issue 9, pp. 2188-95, (2013) (PubMed).
-
- Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))
-
别名
- Caspase-9
-
背景
-
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases.A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3.Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation.Caspase-9 is also activated by granzyme B and CPP32.Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis.Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFalpha, TRAIL, anti-CD-95, FADD, and TRADD.Caspase-9 is expressed in a variety of human tissues.
Synonyms: Mch6, Apaf-3, Casp-9 -
分子量
- 46 kDa
-
UniProt
- P55211
-
途径
- MAPK Pathway, RTK signaling, Apoptosis, Caspase Cascade in Apoptosis, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity
抗原
-