Lamin A/C 抗体 (AA 59-259)
Quick Overview for Lamin A/C 抗体 (AA 59-259) (ABIN1886567)
抗原
See all Lamin A/C (LMNA) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 59-259
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 59 and 259 of Lamin A/C
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应用备注
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Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250 -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- Biohazard Informations: This product contains thimerosal which is hazardous.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Lamin A/C (LMNA)
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别名
- Lamin A/C
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背景
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The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane.The lamin family of proteins make up the matrix and are highly conserved in evolution.During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated.Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression.Vertebrate lamins consist of two types, A and B.Through alternate splicing, this gene encodes three type A lamin isoforms.Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.[provided by RefSeq]
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分子量
- 65 kDa
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基因ID
- 4000
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NCBI登录号
- NP_005563, NM_005572
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途径
- Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
抗原
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