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JNK2 抗体 (C-Term)

Name: JNK2 抗体 (C-Term)
SKU: ABIN1882172
Availability: OutOfStock

This anti-JNK2 antibody is a 兔多克隆 antibody detecting JNK2 in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 4+ publications.

Western blot analysis of anti-JNK2 Pab (ABIN1882172 and ABIN2841614) in Jurkat cell lysate. (JNK2 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (JNK2 抗体 (C-Term))

IHC (p)

2 images

(4 references)

产品编号 ABIN1882172

发货至: 中国

Quick Overview for JNK2 抗体 (C-Term) (ABIN1882172)

抗原

See all JNK2 (MAPK9) 抗体

JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))

适用

人

宿主

兔

克隆类型

多克隆

标记

This JNK2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB2510

Discover our top product MAPK9 Primary Antibody

抗原表位
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AA 349-379, C-Term

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This JNK2 (MAPK9) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-379 amino acids from the C-terminal region of human JNK2 (MAPK9).

亚型

Ig Fraction
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 321-424) antibody
MAPK9 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1D6 unconjugated

anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 321-424) antibody
MAPK9 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2F8 unconjugated

anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 1-424) antibody
MAPK9 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 1C1-3A8 unconjugated

anti-Mitogen-Activated Protein Kinase 9 (MAPK9) antibody
MAPK9 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2G3 unconjugated

anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 227-382) antibody
MAPK9 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2F6H11 unconjugated

anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 130-387) antibody
MAPK9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 1-424) antibody
MAPK9 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 9 (MAPK9) antibody
MAPK9 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 9 (MAPK9) antibody
MAPK9 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 1-424) antibody
MAPK9 适用: 人 ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Tetsunaga, Nishida, Furumatsu, Naruse, Hirohata, Yoshida, Saito, Ozaki: "Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells." in: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society, Vol. 19, Issue 2, pp. 222-32, (2011) (PubMed).

Gupta, Barrett, Whitmarsh, Cavanagh, Sluss, Dérijard, Davis: "Selective interaction of JNK protein kinase isoforms with transcription factors." in: The EMBO journal, Vol. 15, Issue 11, pp. 2760-70, (1996) (PubMed).

Kallunki, Su, Tsigelny, Sluss, Dérijard, Moore, Davis, Karin: "JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation." in: Genes & development, Vol. 8, Issue 24, pp. 2996-3007, (1995) (PubMed).

Sluss, Barrett, Dérijard, Davis: "Signal transduction by tumor necrosis factor mediated by JNK protein kinases." in: Molecular and cellular biology, Vol. 14, Issue 12, pp. 8376-84, (1994) (PubMed).
抗原

JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))

别名

JNK2 (MAPK9)

背景

JNK2 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it. JNK2 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. It is inhibited by dual specificity phosphatases, such as DUSP1. The protein has been shown to bind to at least three scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2 and MAPK8IP3/JIP-3/JSAP1. These proteins also bind other components of the JNK signaling pathway

分子量

48139

NCBI登录号

NP_001128516, NP_002743, NP_620707, NP_620708, NP_620709

UniProt

P45984

途径

MAPK Pathway, WNT signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteins