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SYVN1 抗体 (N-Term)

Name: SYVN1 抗体 (N-Term)
SKU: ABIN1882139
Availability: OutOfStock

SYVN1 适用: 人 WB 宿主: 兔 Polyclonal RB5086 unconjugated

Western blot analysis of anti-HRD1 Pab (ABIN1882139 and ABIN2837883) in mouse brain tissue lysate (35 μg/lane). (SYVN1 抗体 (N-Term))

1 image

(6 references)

产品编号 ABIN1882139

发货至: 中国

Datasheet as PDF

抗原 See all SYVN1 抗体

SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))
抗原表位
16

8

5

5

5

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 58-88, N-Term
适用
53

36

10

7

6

5

4

4

3

3

2

2

2

1

1

1
人
宿主
49

2

2
兔
Compatible Secondaries
克隆类型
51

2
多克隆
标记
29

4

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1
This SYVN1 antibody is un-conjugated
应用范围
44

22

15

13

13

13

7

5

4

3

1

1
Western Blotting (WB)

预测反应

M, X

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This SYVN1 (HRD1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-88 amino acids from the N-terminal region of human SYVN1 (HRD1).

克隆位点

RB5086

亚型

Ig Fraction

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anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 586-617), (C-Term) antibody
SYVN1 适用: 人, 小鼠 WB, IHC (p), IF 宿主: 兔 Polyclonal RB4822 unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 586-617) antibody
SYVN1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (Internal Region) antibody
Verified SYVN1 适用: 人, 大鼠 WB, ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 531-617) antibody
SYVN1 适用: 人, 小鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (Internal Region) antibody
SYVN1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 338-487) antibody
SYVN1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (Internal Region) antibody
SYVN1 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 兔, Bat, 猴, 斑马鱼, Hamster, 非洲爪蟾 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 1-617) antibody
SYVN1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 238-318) antibody
SYVN1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4H4 unconjugated

anti-Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1) (AA 501-550) antibody
SYVN1 适用: 人, 小鼠, 大鼠, 马, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Smith, Granell, Salcedo-Sicilia, Baldini, Egea, Teckman, Baldini: "Activating transcription factor 6 limits intracellular accumulation of mutant ?(1)-antitrypsin Z and mitochondrial damage in hepatoma cells." in: The Journal of biological chemistry, Vol. 286, Issue 48, pp. 41563-77, (2011) (PubMed).

Klemm, Spooner, Ploegh: "Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37602-14, (2011) (PubMed).

Huang, Marvin, Tatsis, Eisenlohr: "Cutting Edge: Selective role of ubiquitin in MHC class I antigen presentation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 4, pp. 1904-8, (2011) (PubMed).

Kikkert, Doolman, Dai, Avner, Hassink, van Voorden, Thanedar, Roitelman, Chau, Wiertz: "Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum." in: The Journal of biological chemistry, Vol. 279, Issue 5, pp. 3525-34, (2004) (PubMed).

Amano, Yamasaki, Yagishita, Tsuchimochi, Shin, Kawahara, Aratani, Fujita, Zhang, Ikeda, Fujii, Miura, Komiya, Nishioka, Maruyama, Fukamizu, Nakajima: "Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy." in: Genes & development, Vol. 17, Issue 19, pp. 2436-49, (2003) (PubMed).

Nadav, Shmueli, Barr, Gonen, Ciechanover, Reiss: "A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1." in: Biochemical and biophysical research communications, Vol. 303, Issue 1, pp. 91-7, (2003) (PubMed).
抗原

SYVN1 (Synovial Apoptosis Inhibitor 1, Synoviolin (SYVN1))

别名

SYVN1 (HRD1) (SYVN1 产品)

别名

DER3 antibody, HRD1 antibody, hrd1 antibody, 1200010C09Rik antibody, AW211966 antibody, C85322 antibody, D530017H19Rik antibody, Hrd1 antibody, RGD1310488 antibody, syvn1 antibody, syvn1-a antibody, syvn1-b antibody, wu:fk91f10 antibody, zgc:55735 antibody, zgc:77108 antibody, synoviolin 1 antibody, synovial apoptosis inhibitor 1, synoviolin antibody, synoviolin 1 S homeolog antibody, SYVN1 antibody, syvn1 antibody, Syvn1 antibody, syvn1.S antibody

背景

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Synoviolin/Hrd1 (expressed in rheumatoid synovium) is reported to be a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. HRD1 contains one ring-type zinc finger.

分子量

67685

NCBI登录号

NP_115807, NP_757385

UniProt

Q86TM6

途径

ER-Nucleus Signaling, Negative Regulation of intrinsic apoptotic Signaling