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MEK1 抗体 (N-Term)

Name: MEK1 抗体 (N-Term)
SKU: ABIN1882101
Availability: OutOfStock

This anti-MEK1 antibody is a 兔多克隆 antibody detecting MEK1 in WB 和 IHC (p). Suitable for 人和小鼠. This Primary Antibody has been cited in 5+ publications.

Western blot analysis of lysates from Jurkat,rat PC-12,mouse NIH/3T3,rat C6 cell line and mouse brain tissue (from left to right),using P2K1 Antibody (P1) (ABIN1882101 and ABIN2842058). (MEK1 抗体 (N-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (MEK1 抗体 (N-Term))

IHC (p)

2 images

(5 references)

产品编号 ABIN1882101

发货至: 中国

Datasheet as PDF

Quick Overview for MEK1 抗体 (N-Term) (ABIN1882101)

抗原

See all MEK1 (MAP2K1) 抗体

MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This MEK1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB3593

Discover our top product MAP2K1 Primary Antibody

抗原表位
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AA 1-30, N-Term

预测反应

Rb, Rat

纯化方法

This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

免疫原

This MEK1 (MAP2K1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MEK1 (MAP2K1).

亚型

Ig Fraction
anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) (AA 2-150) antibody
MAP2K1 适用: 人 ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) antibody
MAP2K1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2H3 unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) antibody
MAP2K1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3H3 unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) (AA 1-100) antibody
MAP2K1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) antibody
MAP2K1 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3B4 unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) (C-Term) antibody
MAP2K1 适用: 人, 小鼠, 大鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) (pSer221) antibody
MAP2K1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) (AA 54-369) antibody
MAP2K1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) (AA 2-79) antibody
MAP2K1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) antibody
MAP2K1 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 3F10 unconjugated Recombinant Antibody

应用备注

WB: 1:1000. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Zheng, Fiumara, Li, Georgakis, Snell, Younes, Vauthey, Carbone, Younes: "MEK/ERK pathway is aberrantly active in Hodgkin disease: a signaling pathway shared by CD30, CD40, and RANK that regulates cell proliferation and survival." in: Blood, Vol. 102, Issue 3, pp. 1019-27, (2003) (PubMed).

Li, Junttila, Han, Kähäri, Westermarck: "p38 Mitogen-activated protein kinase pathway suppresses cell survival by inducing dephosphorylation of mitogen-activated protein/extracellular signal-regulated kinase kinase1,2." in: Cancer research, Vol. 63, Issue 13, pp. 3473-7, (2003) (PubMed).

Zhu, Sun, Lee, Siedlak, Perry, Smith: "Distribution, levels, and activation of MEK1 in Alzheimer's disease." in: Journal of neurochemistry, Vol. 86, Issue 1, pp. 136-42, (2003) (PubMed).

Fringer, Grinnell: "Fibroblast quiescence in floating collagen matrices: decrease in serum activation of MEK and Raf but not Ras." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 20612-7, (2003) (PubMed).

Witowsky, Johnson: "Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways." in: The Journal of biological chemistry, Vol. 278, Issue 3, pp. 1403-6, (2003) (PubMed).
抗原

MEK1 (MAP2K1) (Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))

别名

MEK1 (MAP2K1)

背景

MAP2K1 is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

分子量

43439

NCBI登录号

NP_002746

UniProt

Q02750

途径

MAPK Pathway, RTK signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling