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SQSTM1 抗体 (pSer403)

Name: SQSTM1 抗体 (pSer403)
SKU: ABIN1881831
Availability: OutOfStock

This anti-SQSTM1 antibody is a 兔多克隆 antibody detecting SQSTM1 in DB. Suitable for 人. This Primary Antibody has been cited in 5+ publications.

Dot blot analysis of SQSTM1 Antibody (Phospho ) Phospho-specific Pab (ABIN1881831 and ABIN2839914) on nitrocellulose membrane. (SQSTM1 抗体 (pSer403))

1 image

(5 references)

产品编号 ABIN1881831

发货至: 中国

Datasheet as PDF

Quick Overview for SQSTM1 抗体 (pSer403) (ABIN1881831)

抗原

See all SQSTM1 抗体

SQSTM1 (Sequestosome 1 (SQSTM1))

适用

人

宿主

兔

克隆类型

多克隆

标记

This SQSTM1 antibody is un-conjugated

应用范围

Dot Blot (DB)

克隆位点

RB41445

Discover our top product SQSTM1 Primary Antibody

抗原表位
16

15

11

10

9

8

7

7

6

6

4

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer403

预测反应

M, Rat

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This SQSTM1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S403 of human SQSTM1.

亚型

Ig Fraction
anti-Sequestosome 1 (SQSTM1) antibody
KO Validated SQSTM1 适用: 人 WB, IF, IP, ICC, FACS, IHC (p), PLA 宿主: 兔 Polyclonal unconjugated

anti-Sequestosome 1 (SQSTM1) (AA 51-150) antibody
SQSTM1 适用: 人, 小鼠, 大鼠, Cow WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Sequestosome 1 (SQSTM1) (AA 1-440) antibody
SQSTM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2C11 unconjugated

anti-Sequestosome 1 (SQSTM1) (AA 1-440) antibody
SQSTM1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Sequestosome 1 (SQSTM1) (AA 232-356) antibody
SQSTM1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 5H7E2 unconjugated

anti-Sequestosome 1 (SQSTM1) (AA 317-346) antibody
SQSTM1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB4614 unconjugated

anti-Sequestosome 1 (SQSTM1) (AA 136-400) antibody
SQSTM1 适用: 人 WB, IHC, IP, ICC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Sequestosome 1 (SQSTM1) (C-Term) antibody
SQSTM1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Sequestosome 1 (SQSTM1) antibody
SQSTM1 适用: 人, 猴 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 5A2 unconjugated

anti-Sequestosome 1 (SQSTM1) antibody
KO Validated SQSTM1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

应用备注

DB: 1:500

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Visconti, Langston, Alonso, Goodman, Selby, Fraser, Ralston: "Mutations of SQSTM1 are associated with severity and clinical outcome in paget disease of bone." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 25, Issue 11, pp. 2368-73, (2010) (PubMed).

Ding, Ni, Li, Liao, Chen, Stolz, Dorn, Yin: "Nix is critical to two distinct phases of mitophagy, reactive oxygen species-mediated autophagy induction and Parkin-ubiquitin-p62-mediated mitochondrial priming." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27879-90, (2010) (PubMed).

Jain, Lamark, Sjøttem, Larsen, Awuh, Øvervatn, McMahon, Hayes, Johansen: "p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription." in: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22576-91, (2010) (PubMed).

Lau, Wang, Zhao, Villeneuve, Wu, Jiang, Sun, White, Zhang: "A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62." in: Molecular and cellular biology, Vol. 30, Issue 13, pp. 3275-85, (2010) (PubMed).

Gao, Cao, Bao, Zuo, Xie, Cai, Fu, Zhang, Wu, Zhang, Chen: "Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation." in: Nature cell biology, Vol. 12, Issue 8, pp. 781-90, (2010) (PubMed).
抗原

SQSTM1 (Sequestosome 1 (SQSTM1))

别名

SQSTM1

背景

This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone.

分子量

47687

NCBI登录号

NP_001135770, NP_001135771, NP_003891

UniProt

Q13501

途径

NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy