我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

Retinoblastoma 1 抗体 (AA 586-615)

Name: Retinoblastoma 1 抗体 (AA 586-615)
SKU: ABIN1881730
Availability: OutOfStock

Cited in 4+ publications. This 兔多克隆 anti-Retinoblastoma 1 antibody (Clone RB7977) specifically detects Retinoblastoma 1 in WB, IF 和 IHC (p). The antibody is reactive with 人 samples.

Rb Antibody (ABIN1881730 and ABIN2840685) western blot analysis in Daudi,Raji cell line lysates (35 μg/lane). (Retinoblastoma 1 抗体 (AA 586-615))

RB1 Antibody (ABIN1881730 and ABIN2840685) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. (Retinoblastoma 1 抗体 (AA 586-615))

IHC (p)

Confocal immunofluorescent analysis of RB1 Antibody (ABIN1881730 and ABIN2840685) with MDA-M cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). (Retinoblastoma 1 抗体 (AA 586-615))

3 images

(4 references)

产品编号 ABIN1881730

发货至: 中国

Contact our Customer Service for availability and price in your country. Contact Info

Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Retinoblastoma 1 抗体 (AA 586-615) (ABIN1881730)

抗原

See all Retinoblastoma 1 (RB1) 抗体

Retinoblastoma 1 (RB1)

适用

人

宿主

兔

克隆类型

多克隆

标记

This Retinoblastoma 1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB7977

Discover our top product RB1 Primary Antibody

抗原表位
30

30

20

19

18

17

15

14

6

6

5

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 586-615

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This RB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 586-615 amino acids from human RB1.

亚型

Ig Fraction
anti-Retinoblastoma 1 (RB1) (pSer780) antibody
RB1 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer795) antibody
RB1 适用: 人 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer780) antibody
RB1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer780) antibody
RB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer807) antibody
RB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer795) antibody
RB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (C-Term) antibody
RB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (C-Term) antibody
RB1 适用: 人 WB, IF, IP, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (pSer807), (pSer811) antibody
RB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Retinoblastoma 1 (RB1) (AA 639-778) antibody
RB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Dasgupta, Sun, Wang, Fusaro, Betts, Padmanabhan, Sebti, Chellappan: "Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis." in: Molecular and cellular biology, Vol. 24, Issue 21, pp. 9527-41, (2004) (PubMed).

Cui, Shirai, Wakai, Yokoyama, Hirano, Hatakeyama: "Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma." in: Human pathology, Vol. 35, Issue 10, pp. 1189-95, (2004) (PubMed).

Borah, Verma, Robertson: "ORF73 of herpesvirus saimiri, a viral homolog of Kaposi's sarcoma-associated herpesvirus, modulates the two cellular tumor suppressor proteins p53 and pRb." in: Journal of virology, Vol. 78, Issue 19, pp. 10336-47, (2004) (PubMed).

Dasgupta, Betts, Rastogi, Joshi, Morris, Brennan, Ordonez-Ercan, Chellappan: "Direct binding of apoptosis signal-regulating kinase 1 to retinoblastoma protein: novel links between apoptotic signaling and cell cycle machinery." in: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 38762-9, (2004) (PubMed).
抗原

Retinoblastoma 1 (RB1)

别名

RB1

背景

The retinoblastoma protein is a tumor suppressor protein that is dysfunctional in many types of cancer.[1] One highly studied function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins.[2][3] Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomaviruses, bind and inactivate pRb, this can lead to cancer. Retinoblastoma (RB) is an embryonic malignant neoplasm of retinal origin. It almost always presents in early childhood and is often bilateral.

分子量

106159

NCBI登录号

NP_000312

UniProt

P06400

途径

Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy