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IKK alpha 抗体 (C-Term)

This anti-IKK alpha antibody is a 兔 多克隆 antibody detecting IKK alpha in WB. Suitable for 人. This Primary Antibody has been cited in 5+ publications.
产品编号 ABIN1881204
发货至: 中国

Quick Overview for IKK alpha 抗体 (C-Term) (ABIN1881204)

抗原

See all IKK alpha (CHUK) 抗体
IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

适用

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宿主

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克隆类型

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多克隆

标记

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This IKK alpha antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

RB41164
  • 抗原表位

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    AA 553-582, C-Term

    预测反应

    B

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This CHUK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human CHUK.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • Lahtela, Nousiainen, Stefanovic, Tallila, Viskari, Karikoski, Gentile, Saloranta, Varilo, Salonen, Kestilä: "Mutant CHUK and severe fetal encasement malformation." in: The New England journal of medicine, Vol. 363, Issue 17, pp. 1631-7, (2010) (PubMed).

    Gouin, Adib-Conquy, Balestrino, Nahori, Villiers, Colland, Dramsi, Dussurget, Cossart: "The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 40, pp. 17333-8, (2010) (PubMed).

    Cummins, Oliver, Lenihan, Fitzpatrick, Bruning, Scholz, Slattery, Leonard, McLoughlin, Taylor: "NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4439-45, (2010) (PubMed).

    Li, Morgan, Choksi, Zhang, Kim, Liu: "MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation." in: Nature immunology, Vol. 11, Issue 9, pp. 799-805, (2010) (PubMed).

    Rotman, Koh, Zmuda, Kleiner, Liang: "The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 3, pp. 894-903, (2010) (PubMed).

  • 抗原

    IKK alpha (CHUK) (conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK))

    别名

    CHUK

    背景

    This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.

    分子量

    84640

    NCBI登录号

    NP_001269

    UniProt

    O15111

    途径

    PI3K-Akt Signaling, NF-kappaB Signaling, RTK signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
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