电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

CHEK2 抗体 (N-Term)

This anti-CHEK2 antibody is a 兔 多克隆 antibody detecting CHEK2 in WB, IF, IHC (p) 和 FACS. Suitable for 人. This Primary Antibody has been cited in 5+ publications.
产品编号 ABIN1881196
发货至: 中国

Quick Overview for CHEK2 抗体 (N-Term) (ABIN1881196)

抗原

See all CHEK2 抗体
CHEK2 (Checkpoint Kinase 2 (CHEK2))

适用

  • 238
  • 86
  • 72
  • 16
  • 13
  • 7
  • 6
  • 5
  • 4
  • 2
  • 2
  • 1

宿主

  • 219
  • 22
  • 1

克隆类型

  • 207
  • 35
多克隆

标记

  • 113
  • 11
  • 9
  • 9
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
This CHEK2 antibody is un-conjugated

应用范围

  • 203
  • 79
  • 78
  • 71
  • 44
  • 38
  • 34
  • 27
  • 23
  • 21
  • 18
  • 5
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

克隆位点

RB19067
  • 抗原表位

    • 26
    • 25
    • 19
    • 17
    • 16
    • 16
    • 15
    • 15
    • 9
    • 8
    • 8
    • 7
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 111-141, N-Term

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This CHEK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-141 amino acids from the N-terminal region of human CHEK2.

    亚型

    Ig Fraction
  • 应用备注

    IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • Xiao, Zheng, Huang, Liu, Zhang, Ma: "Deficiency of 53BP1 inhibits the radiosensitivity of colorectal cancer." in: International journal of oncology, Vol. 49, Issue 4, pp. 1600-8, (2017) (PubMed).

    Yao, Huang, Zheng, Liu, Lin, Zhang, Yang, Zhang, Ma: "53BP1 loss induces chemoresistance of colorectal cancer cells to 5-fluorouracil by inhibiting the ATM-CHK2-P53 pathway." in: Journal of cancer research and clinical oncology, Vol. 143, Issue 3, pp. 419-431, (2017) (PubMed).

    Yang, Wood, Hrushesky: "Mammalian TIMELESS is required for ATM-dependent CHK2 activation and G2/M checkpoint control." in: The Journal of biological chemistry, Vol. 285, Issue 5, pp. 3030-4, (2010) (PubMed).

    Varmark, Kwak, Theurkauf: "A role for Chk2 in DNA damage induced mitotic delays in human colorectal cancer cells." in: Cell cycle (Georgetown, Tex.), Vol. 9, Issue 2, pp. 312-20, (2010) (PubMed).

    Zhu, Miao, Huang, Feng, Zhang, Lu, Cai, Tong, Xu, Qian, Ding: "Naphthalimides induce G(2) arrest through the ATM-activated Chk2-executed pathway in HCT116 cells." in: Neoplasia (New York, N.Y.), Vol. 11, Issue 11, pp. 1226-34, (2009) (PubMed).

  • 抗原

    CHEK2 (Checkpoint Kinase 2 (CHEK2))

    别名

    CHEK2

    背景

    CHEK2 is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53.

    分子量

    60915

    NCBI登录号

    NP_001005735, NP_001244316, NP_009125, NP_665861

    UniProt

    O96017

    途径

    p53 Pathway, Apoptosis, Cell Division Cycle
You are here:
Chat with us!