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Caspase 9 抗体 (Ser196)

Name: Caspase 9 抗体 (Ser196)
SKU: ABIN1881137
Availability: OutOfStock

This anti-Caspase 9 antibody is a 兔多克隆 antibody detecting Caspase 9 in WB, FACS 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 5+ publications.

Western blot analysis of anti-CASP9 Antibody (ABIN1881137 and ABIN2842071) in Jurkat cell line lysates (35 μg/lane). (Caspase 9 抗体 (Ser196))

Flow cytometric analysis of MDA-231 cells using CASP9 Antibody (bottom histogram) compared to a negative control cell (top histogram). (Caspase 9 抗体 (Ser196))

FACS

Formalin-fixed and paraffin-embedded human hepatocarcinoma with CASP9 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (Caspase 9 抗体 (Ser196))

IHC (p)

3 images

(5 references)

产品编号 ABIN1881137

发货至: 中国

Datasheet as PDF

Quick Overview for Caspase 9 抗体 (Ser196) (ABIN1881137)

抗原

See all Caspase 9 (CASP9) 抗体

Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

适用

人

宿主

兔

克隆类型

多克隆

标记

This Caspase 9 antibody is un-conjugated

应用范围

Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB6899

Discover our top product CASP9 Primary Antibody

抗原表位
28

16

16

16

16

11

9

5

5

5

4

4

4

4

4

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Ser196

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This CASP9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S196 of human CASP9.

亚型

Ig Fraction
anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 1-98) antibody
CASP9 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 11-120) antibody
CASP9 适用: 人, 小鼠, 大鼠, 兔, 小鸡, 犬 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 331-416) antibody
CASP9 适用: 人 WB, FACS 宿主: 兔 Polyclonal unconjugated

anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 1-200) antibody
CASP9 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 1-200) antibody
CASP9 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 1-416) antibody
CASP9 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3B8-4G2 unconjugated

anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (AA 271-314) antibody
CASP9 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) antibody
CASP9 适用: 人 WB, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (pThr125) antibody
CASP9 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9) (Cleaved-Asp353) antibody
CASP9 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Martin, Allan, Lickrish, Sampson, Morrice, Clarke: "Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c." in: The Journal of biological chemistry, Vol. 280, Issue 15, pp. 15449-55, (2005) (PubMed).

Raina, Pandey, Ahmad, Bharti, Ren, Kharbanda, Weichselbaum, Kufe: "c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage." in: The Journal of biological chemistry, Vol. 280, Issue 12, pp. 11147-51, (2005) (PubMed).

Cornelis, Bruynooghe, Van Loo, Saelens, Vandenabeele, Beyaert: "Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1." in: Oncogene, Vol. 24, Issue 9, pp. 1552-62, (2005) (PubMed).

Mohammad, Wang, Aboukameel, Chen, Wu, Chen, Al-Katib: "Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma." in: Molecular cancer therapeutics, Vol. 4, Issue 1, pp. 13-21, (2005) (PubMed).

Tacconi, Perri, Balestrieri, Grelli, Bernardini, Annichiarico, Mastino, Caltagirone, Macchi: "Increased caspase activation in peripheral blood mononuclear cells of patients with Alzheimer's disease." in: Experimental neurology, Vol. 190, Issue 1, pp. 254-62, (2004) (PubMed).
抗原

Caspase 9 (CASP9) (Caspase 9, Apoptosis-Related Cysteine Peptidase (CASP9))

别名

CASP9

背景

Caspase 9 is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1, this step is thought to be one of the earliest in the caspase activation cascade.

分子量

46281

NCBI登录号

NP_001220, NP_001264983, NP_127463

UniProt

P55211

途径

MAPK Pathway, RTK signaling, Apoptosis, Caspase Cascade in Apoptosis, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity