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Caspase 8 抗体 (N-Term)

This anti-Caspase 8 antibody is a 小鼠 单克隆 antibody detecting Caspase 8 in WB. Suitable for 人.
产品编号 ABIN187519
发货至: 中国

Quick Overview for Caspase 8 抗体 (N-Term) (ABIN187519)

抗原

See all Caspase 8 (CASP8) 抗体
Caspase 8 (CASP8)

适用

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  • 1
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宿主

  • 134
  • 26
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小鼠

克隆类型

  • 131
  • 35
单克隆

标记

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This Caspase 8 antibody is un-conjugated

应用范围

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Western Blotting (WB)

克隆位点

FLICE-1
  • 抗原表位

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    • 2
    • 1
    • 1
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    N-Term

    过滤

    0.2 μm filtered

    免疫原

    Recombinant human caspase-8.

    亚型

    IgG1
  • 应用备注

    Western Blot The optimal dilution for a specific application should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Mouse monoclonal antibody against human Caspase-8 (cysteine-requiring aspartate protease-8). Available in 100 µl vials at a concentration of 1 mg/ml (100 µg) in PBS with 0.08% sodium azide. Antibody was purified by 0.2 µm sterile filtration.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C
  • 抗原

    Caspase 8 (CASP8)

    别名

    Caspase-8

    背景

    Caspases are key effectors of programmed cell death. They are synthesized as inactive pro-enzymes, which are activated by cleavage at a specific aspartate residue to form two subunits. These subunits are normally linked together by a linker, which may be involved in the regulation of the different caspases. Caspase-8 is a key enzyme in the apoptosis pathway. Caspase-8 contains two N-terminal region death effector domains, which are removed to activate the enzyme along with cleavage in the two subunits. These subunits then form the active protease, which is capable of cleaving caspase-3, -6 and -7. These caspases are then capable of cleaving other cellular substrates such as PARP and DFF, which in turn induce apoptosis.

    途径

    Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
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