CYB5R3 抗体 (Cy5.5)
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- 抗原 See all CYB5R3 抗体
- CYB5R3 (Cytochrome B5 Reductase 3 (CYB5R3))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CYB5R3 antibody is conjugated to Cy5.5
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应用范围
- Western Blotting (WB)
- 交叉反应
- 小鼠
- 预测反应
- Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human CYB5R3
- 亚型
- IgG
- Top Product
- Discover our top product CYB5R3 Primary Antibody
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- 应用备注
- IF(IHC-P) 1:50-200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- CYB5R3 (Cytochrome B5 Reductase 3 (CYB5R3))
- 别名
- Cyb5r3 (CYB5R3 产品)
- 别名
- B5R antibody, DIA1 antibody, Dia1 antibody, Nadhcb5 antibody, RNNADHCB5 antibody, 0610016L08Rik antibody, 2500002N19Rik antibody, C85115 antibody, Dia-1 antibody, WU:AL591952.1-001 antibody, WU:AL591952.1-002 antibody, WU:AL591952.1-003 antibody, WU:Cyb5r3 antibody, fc32h03 antibody, zgc:77071 antibody, wu:fc32h03 antibody, dia1 antibody, CB5R antibody, DDBDRAFT_0218707 antibody, DDBDRAFT_0266821 antibody, DDB_0218707 antibody, DDB_0266821 antibody, cytochrome b5 reductase 3 antibody, cytochrome b5 reductase 3 L homeolog antibody, NADH-cytochrome b5 reductase antibody, CYB5R3 antibody, Cyb5r3 antibody, cyb5r3 antibody, cyb5r3.L antibody, CNM00240 antibody, Tb11.47.0018 antibody, cyb5r1 antibody
- 背景
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Synonyms: B5R, Cyb5r3, Cytochrome b5 reductase 3, Cytochrome b5 reductase, DIA1, Diaphorase 1, Diaphorase-1, NADH cytochrome b5 reductase 3, NADH-cytochrome b5 reductase 3 membrane-bound form, NADH-cytochrome b5 reductase 3 soluble form, NB5R3_HUMAN, OTTHUMP00000028761, OTTHUMP00000198435, OTTHUMP00000198574, OTTHUMP00000198662, OTTHUMP00000198665.
Background: CYB5R3 is a 301 amino acid protein encoded by the human gene CYB5R3. CYB5R3 belongs to the flavoprotein pyridine nucleotide cytochrome reductase family and has two naturally occuring isoforms. Isoform 1 is anchored to the cytoplasmic side of the endoplasmic reticulum membrane and mitochondrion outer membrane, while isoform 2 is the soluble form found in erythrocytes. CYB5R3 is involved in the desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism and, in erythrocytes, methemoglobin reduction. A serine residue at position 117 seems to only be found in persons of African origin. The allele frequency is 0.23 in African Americans. It is not found in Caucasians, Asians, Indo-Aryans or Arabs. This difference seems to have no effect on the enzyme activity. Defects in CYB5R3 are the cause of hereditary methemoglobinemia (HM). There are three forms of this disease: type 1 (HM1), in which the enzyme is only deficient in erythrocytes with a mild cyanosis, type 2 (HM2), in which the enzyme is completely deficient, and type 3 (HM3), where the deficiency is seen in all blood cells. Type 2 is a severe form accompanied by mental retardation and neurological impairment.
- 基因ID
- 1727
- 途径
- SARS-CoV-2 Protein Interactome
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