FGFR3 抗体 (AA 39-138)
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Quick Overview for FGFR3 抗体 (AA 39-138) (ABIN1679839)
抗原
See all FGFR3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 39-138
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序列
- PGPEPGQQEQ LVFGSGDAVE LSCPPPGGGP MGPTVWVKDG TGLVPSERVL VGPQRLQVLN ASHEDSGAYS CRQRLTQRVL CHFSVRVTDA PSSGDDEDGE
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交叉反应
- 人, 小鼠, 大鼠
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产品特性
- Polyclonal Antibodies
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纯化方法
- Affinity purification
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免疫原
- Recombinant fusion protein containing a sequence corresponding to amino acids 39-138 of human FGFR3 (NP_000133.1).
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亚型
- IgG
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应用备注
- WB,1:500 - 1:2000,IHC,1:50 - 1:100,IF,1:50 - 1:200
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限制
- 仅限研究用
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缓冲液
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Avoid freeze / thaw cycles.
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- FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
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别名
- FGFR3
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背景
- This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.,ACH,CD333,CEK2,HSFGFR3EX,JTK4,FGFR3,Cancer,Signal Transduction,Kinase,Tyrosine kinases,Cell Biology & Developmental Biology,Growth factor,ESC Pluripotency and Differentiation,Immunology & Inflammation,CD markers,Stem Cells,Neural Stem Cells,Cardiovascular,Angiogenesis,FGFR3
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分子量
- 75 kDa/85 kDa/87 kDa/88 kDa
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基因ID
- 2261
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UniProt
- P22607
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding
抗原
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