FLT1 抗体 (Soluble)
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- 抗原 See all FLT1 抗体
- FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
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抗原表位
- Soluble
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FLT1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- Peptide: GEHCNKKAVFSRISKFKSTR NDSTTQSNVKH.
- 产品特性
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Chromosomal location: 13q12
Produced from sera of rabbits immunised with a peptide of the C-terminal end of native human soluble VEGFR-1/Flt-1 (CNKKAVFSRISKFKSTRNDSTTQSNVKH). - 纯化方法
- Anti-human soluble VEGFR-1/Flt-1 was purified by affinity chromatography with immobilized Protein A.
- 亚型
- IgG
- Top Product
- Discover our top product FLT1 Primary Antibody
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- 应用备注
- Western Blot: use 1-5 µg/mL
- 说明
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Rabbit IG Polyclonal Antibody
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Reconstitute in sterile water to a concentration of 0.1-1.0 mg/mL.
- 缓冲液
- PBS
- 注意事项
- Centrifuge vial prior to opening.
- 储存条件
- -20 °C
- 储存方法
- The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
- 有效期
- 6 months
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- 抗原
- FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
- 别名
- VEGFR-1/Flt-1 (FLT1 产品)
- 别名
- FLT antibody, FLT-1 antibody, VEGFR-1 antibody, VEGFR1 antibody, FLT1 antibody, flt1b antibody, sFlt1 antibody, AI323757 antibody, Flt-1 antibody, fms related tyrosine kinase 1 antibody, FMS-related tyrosine kinase 1 antibody, vascular endothelial growth factor receptor 1 antibody, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody, FMS-like tyrosine kinase 1 antibody, vascular endothelial growth factor receptor-1 antibody, FLT1 antibody, Flt1 antibody, CpipJ_CPIJ012087 antibody, flt1 antibody, FLT-1 antibody
- 背景
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Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes, dendritic cells and on trophoblast cells. The flt-1 gene was first described in 1990. The receptor contains seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular splited tyrosine kinase domain. Compared to VEGFR-2 the Flt-1 receptor has a higher affinity for VEGF but a weaker signaling activity. VEGFR-1 thus leads not to proliferation of endothelial cells, but mediates signals for differentiation. Interestingly a naturally occuring soluble variant of VEGFR-1 (sVEGFR-1) was found in HUVE supernatants in 1996, which is generated by alternative splicing of the flt-1 mRNA.
Synonyms: soluble vascular endothelial growth factor receptor-1, soluble FLT1, soluble FLT, soluble VEGF receptor 1 - NCBI登录号
- NM_001159920, NP_001153392
- UniProt
- P17948
- 途径
- RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals
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