LAMP1 抗体
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- 抗原 See all LAMP1 抗体
- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
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适用
- 人, 小鼠, 大鼠, Pig, Cow, 哺乳动物
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This LAMP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 纯化方法
- affinity purified antibody
- 克隆位点
- 6E2
- 亚型
- IgG1
- Top Product
- Discover our top product LAMP1 Primary Antibody
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anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (AA 80-280) antibody
LAMP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (AA 301-417) antibodyLAMP1 适用: 人, 小鼠, 大鼠, 猴 WB, FACS, ELISA, ICC, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (AA 49-297) antibodyLAMP1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibodyLAMP1 适用: 人, 小鼠, Non-Human Primate WB, FACS, ICC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal H4A3 unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibodyLAMP1 适用: 大鼠 WB, IF, IP, ICC 宿主: 小鼠 Monoclonal Ly1C6 unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) (AA 125-154) antibodyLAMP1 适用: 人, 小鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibodyLAMP1 适用: 人, 小鼠, 灵长类 WB, FACS, IHC, ICC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal H4A3 unconjugated
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody (FITC)LAMP1 适用: 小鼠 WB, FACS, IHC, IP, IHC (p), IHC (fro) 宿主: 大鼠 Monoclonal FITC
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibody (APC)LAMP1 适用: 人, 小鼠, Non-Human Primate FACS 宿主: 小鼠 Monoclonal H4A3 APC
anti-Lysosomal-Associated Membrane Protein 1 (LAMP1) antibodyLAMP1 适用: 人, Green Monkey WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 3C3 unconjugated
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- 应用备注
- The antibody solution can be used at dilutions of at least 1:2,000 in immunofluorescence experiments. In western blotting using chemiluminescence it can be used at dilutions of 1:10,000 or lower.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 4°C short term or -20°C long term.
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- 抗原
- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
- 别名
- Lamp1 (LAMP1 产品)
- 别名
- CD107a antibody, LAMPA antibody, LGP120 antibody, AI196048 antibody, Lamp-1 antibody, LEP100 antibody, LAMP-1 antibody, LGP-A antibody, Lgpa antibody, Lysosome-associated membrane protein 1 antibody, cd107a antibody, lamp-1 antibody, lamp1 antibody, lampa antibody, lgp120 antibody, rexp76 antibody, lysosomal associated membrane protein 1 antibody, lysosomal-associated membrane protein 1 antibody, lysosomal-associated membrane protein 1 L homeolog antibody, LAMP1 antibody, Lamp1 antibody, lamp1.L antibody
- 背景
- As the name suggests, LAMP1 is a protein primarily associated with the lysosomal membrane. Antibodies to LAMP1 are therefore excellent markers of lysosomes in mammalian cells, though some LAMP1 may also be seen on late endosomes and on the plasma membrane. In a typical cell LAMP1 is associated with spherical vesicles located next to the nucleus and the microtubule organizing center. The protein is also known as CD107a, lysosomal associated membrane glycoprotein 1, LGP120 and LAMPA, as the protein was independently discovered and named by several different labs. CD is an abbreviation for Cluster of Differentiation and refers to a protocol for the naming of proteins and other surface markers of membranes of human leucocytes defined by binding of specific monoclonal antibodies. LAMP1 is found on the cell surface of lymphocytes undergoing degranulation, a process in which cytoplasmic vesicles fuse with the plasma membrane, and this phenomena resulted in discovery of LAMP1 as a CD protein. The LAMP1 protein has a large N-terminal region which is inside the lysosome, hence topologically external to the cell, which is often refered to as the lumenal domain. The lumenal domain consists of two homologous globular seqments separated by a proline rich sequence. Next there is a single membrane spanning domain and a short 11 amino acid C-terminal cytoplasmic tail. This tail region contains, at the extreme C-terminus, a so-called YXXI motif which is responsible for the sorting of the intact molecule to the endosome and lysozome, where Y = tyrosine, I = isoleucine and X = almost any amino acid. This motif is found in several other lysosomal proteins, where it functions in the same way. There are 417 amino acids in the human LAMP1 molecule, giving a native molecular weight of 44.8 kDa. However the N-terminal lumenal segment of LAMP1 is very heavily and variably glycosylated due to the presence of 18 N-linked glycosylation sites, so that on SDS-PAGE and on Western blots the protein runs as a diffuse band at 90-120 kDa. The HGNC name for this protein is LAMP1.
- 途径
- Autophagy
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