BCL2L1 抗体
Our Local Distributor
北京 101111
Quick Overview for BCL2L1 抗体 (ABIN155068)
抗原
See all BCL2L1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
特异性
- The antibody detects the 30 kDa Bcl-xL protein. It does not react with other Bcl-2 family members.
-
纯化方法
- Purified
-
免疫原
- Synthetic peptide surrounding amino acid 56 of human Bcl-xL
-
-
-
-
应用备注
-
Western Blot: 0.5-4 μg/mL. Immunoprecipitation: 20 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 0.5 mg/mL
-
缓冲液
- PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA and 0.01 % thimerosal
-
储存液
- Thimerosal (Merthiolate)
-
注意事项
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C/-80 °C
-
储存方法
- Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
-
-
- BCL2L1 (BCL2-Like 1 (BCL2L1))
-
别名
- Bcl-2-Like 1
-
背景
- Bcl-xL is a 30 kDa anti-apoptotic protein belonging to the Bcl-2 family. Bcl-xL prevents apoptosis through two different mechanisms: by heterodimerization with an apoptotic protein to inhibit its apoptotic effect, and by its direct pore-forming effect on the outer-membrane of mitochondria to help maintain a normal membrane state under stress conditions. Bcl-xL can be cleaved by caspases upon apoptotic activation, which converts Bcl-xL from an antiapoptotic protein to a proapoptotic cleavage product. The cleavage product of Bcl-xL forms cytochrome c-releasing pores in the mitochondrial membrane to facilitate the apoptosis signaling pathway.Synonyms: BCL2L, BCL2L1, BCLX, Bcl-2-like protein 1, Bcl-x, Bcl2-L-1, bcl-xL, bcl-xS
-
基因ID
- 9606
-
UniProt
- Q07817
-
途径
- Apoptosis, Negative Regulation of intrinsic apoptotic Signaling
抗原
-